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Clinical Guide to Transplantation in Lymphoma

Bipin N. Savani, Mohamad Mohty

ISBN: 978-1-118-86327-5 June 2015 Wiley-Blackwell 288 Pages



The first book on clinical guide to transplantation in lymphoma to present cutting edge knowledge on how to integrate, transplantation and novel therapies in patients with lymphoid malignancies
  • Provides practical management guidance on how to integrate, transplantation and novel therapies in patients with lymphoid malignancies
  • Covers an overview of transplantation in lymphoma, and management of the lymphoid malignancies
  • Discusses organizational aspects of transplant patients and managing a transplant program
  • Appendices provide practical quick-reference information on follow-up after autologous and allogenic stem cell transplantation in lymphoma

List of contributors vii

Foreword xi

Introduction 1

Section 1: Transplantation in lymphomas

1 Lymphoma and transplantation: historical perspective 5
Andrew R. Rezvani

2 Lymphoma: working committee and data reporting after transplantation in lymphoma 13
Wael Saber, Mehdi Hamadani, Shahrukh Hashmi and Parameswaran Hari

3 Use of transplantation in lymphoma: adults 23
Parastoo Bahrami Dahi, Gabriela Soriano Hobbs and Miguel]Angel Perales

4 Hematopoietic stem cell transplantation for lymphoma in children, adolescents, and young adults 31
Nader Kim El]Mallawany and Mitchell S. Cairo

5 Preparative regimens for lymphoma: autologous hematopoietic stem cell transplantation 45
Taiga Nishihori, Karma Z. Salem, Ernesto Ayala and Mohamed A. Kharfan]Dabaja

6 Preparative regimens for lymphoma: allogeneic hematopoietic stem cell transplantation 57
Mohamed A. Kharfan]Dabaja, Najla El]Jurdi, Mehdi Hamadani and Ernesto Ayala

7 Pretransplantation evaluation, comorbidities, and nondisease]related eligibility criteria for transplantation in lymphoma, 69
Melissa Logue

8 Stem cell mobilization in lymphoma patients 75
Tarah Ballinger, Bipin N. Savani and Mohamad Mohty

9 Allogeneic hematopoietic stem cell transplantation for lymphoma: stem cell source, donor, and HLA matching 85
Michael Green and Mitchell Horwitz

10 Management of early and late toxicities of autologous hematopoietic stem cell transplantation 93
Sai Ravi Pingali and Yago Nieto

11 Long]term follow]up of lymphoma patients after allogeneic hematopoietic cell transplantation 103
Shylaja Mani and Navneet S. Majhail

12 First 100 days of the autologous hematopoietic stem cell transplantation process in lymphoma 109
Angela Moreschi Woods

13 First 100 days of the allogeneic hematopoietic stem cell transplantation process in lymphoma 113
Angela Moreschi Woods

Section 2: Management

14 Stem cell transplantation in follicular lymphoma,119
Satyajit Kosuri and Koen Van Besien

15 Chronic lymphocytic leukemia/small lymphocytic lymphoma 133
Salyka Sengsayadeth and Wichai Chinratanalab

16 Diffuse large B]cell lymphoma 145
Lauren Veltri, Bipin N. Savani, Mohamed A. Kharfan]Dabaja, Mehdi Hamadani and Abraham S. Kanate

17 Mantle cell lymphoma 161
Sascha Dietrich and Peter Dreger

18 Hodgkin lymphoma 173
Eva Domingo]Domenech and Anna Sureda

19 Peripheral T]cell lymphomas 187
Giulia Perrone, Chiara De Philippis, Lucia Farina and Paolo Corradini

20 Transplantation in Burkitt and lymphoblastic lymphoma 201
Gregory A. Hale

21 Transplantation in adult T]cell leukemia/lymphoma 209
Ali Bazarbachi and Olivier Hermine

22 Hematopoietic cell transplantation for HIV]related lymphomas 217
Joseph C. Alvarnas

23 Stem cell transplantation for mycosis fungoides/Sézary syndrome 233
Eric D. Jacobsen

24 Role of transplantation in lymphoplasmacytic lymphoma 241
Silvia Montoto and Charalampia Kyriakou

25 Transplantation outcome in primary mediastinal large B]cell lymphoma 247
Amanda F. Cashen

26 Management of post]transplant lymphoproliferative disorders 253
Jan Styczynski and Per Ljungman

Appendix I Follow]up calendar after autologous stem cell transplantation in lymphoma 261
Angela Moreschi Woods

Appendix II Follow]up calendar after allogeneic stem cell transplantation in lymphoma 263
Angela Moreschi Woods

Index 265

Sir William Osler is reputed to have said, “Listen to the patient and he will give you the answer.” Had he been alive now and practicing transplantation for lymphoma, he could have well said “Read the Clinical Guide to Transplantation in Lymphoma and it will give you the answer.” These reviewers are very impressed by the breadth and scope of this book edited by Drs. Bipin Savani and Mohamed Mohty, ably aided by an array of expert contributors from all over the world.

Clinical Guide to Transplantation in Lymphoma is extremely easy to read and very well written. In this era of
exponential information growth this book is surprisingly current, with the latest references. It has an ambitious scope, setting out to cover all aspects of transplantation in lymphoma and managing to meet that expectation.

Chapters are laid out in logical sequence divided into 2 sections. Section 1 is particularly interesting and has
chapters on the historical perspective of transplantation for lymphoma, transplant data collection and reporting, and analytical methods. The remainder of section 1 describes the general principles of transplantation in lymphomas, addressing issues such as mobilization, preparative regimens, and management of the early, late, and long-term issues arising after transplantation. Some chapters include transplantation for lymphoma in children, adults, and young adolescents; pretransplant evaluation; preparative regimens for autologous and allogeneic transplants; stem cell mobilization and stem cell source; post-transplant follow-up for autologous
and allogeneic transplant, and a novel chapter, “First 100 Days of the Autologous Hematopoietic Stem Cell Transplantation Process in Lymphoma.” The chapters in section 1 are broadly applicable and would prove invaluable to trainees pursuing fellowships in hematopoietic cell transplantation.

Section 2 is laid out as a chapter by chapter discussion of various lymphoma histologies and the applicability of hematopoietic cell transplantation in each. One can return to some of these chapters again and again because all common and most rare lymphoma subtypes (including HIV-associated lymphoma) are discussed in excellent detail. We found each one of these chapters to be remarkably up to date. In a field such ashematopoietic cell transplantation,where there is considerable ambiguity and few randomized studies, the authors and editors have maintained a neutral and unbiased tone,discussing the available data andguidelines exhaustively.

Very few similar textbooks focus on transplantation in a disease group. Clinical Guide to Transplantation in Lymphoma is concise enough, practical, and clinically oriented to be considered a practical manual but at the same time manages to be comprehensive. Some unique features in this book are the numerous excellent graphs and tables and the discussion of case studies and clinical guidelines (United States and European) wherever applicable. We found very few typographic errors. For future editions we recommend at least 1 chapter devoted to the emerging field of cellular immunotherapy.

The editors and the contributors need to be congratulated for an encyclopedic work that still manages to be a ready reference guide. This book will be used extensively and should be in the library of every transplanter.We hope it runs into many future editions and becomes the authoritative textbook for transplantation in lymphoma. (Yogesh Jethava, Parameswaran Hari, University of Arkansas for Medical Science, Biology of Blood and Marrow Transplantation, Nov 2015)