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Acute Ischemic Stroke: An Evidence-based Approach

Acute Ischemic Stroke: An Evidence-based Approach

David M. Greer (Editor)

ISBN: 978-0-470-18339-7 March 2007 384 Pages



This focused book deals clearly and concisely with the principles of management of patients with acute ischemic stroke (AIS). It emphasizes the published and verifiable evidence in support of these principles, and highlights the areas of limited evidence. Best evidence is provided for the current standard treatment of acute ischemic stroke, including intravenous chemical thrombolysis, intra-arterial approaches, blood pressure management, and anti-thrombotic therapy. More modern techniques are also described, such as the use of mechanical devices to evacuate a thrombus, induced hypertension, hyper-oxygenation (hyperoxia), and neuroprotective or neuroregeneration agents. Hallmark features include:
  • Focused on acute ischemic stroke, the most rapidly growing area of stroke management
  • Evidence based: Provides best evidence for treatment
  • Clearly discusses areas and topics where best evidence has not yet been established
  • Lays out treatment plans and protocols in handbook fashion for ease of use and reference, even in emergency situations
  • Includes latest and cutting-edge techniques and equipment for dealing with AIS

Acute Ischemic Stroke: An Evidence-based Approach is an indispensable reference work for neurologists, neurocritical care medics, intensivists, hospitalists, emergency room physicians, neurology residents and fellows. It is also a helpful resource for medical students, physician assistants, and nurse practitioners in hospital and neurocritical care facilities.

Preface vii

Contributors ix

1. Stroke: Historical Perspectives and Future Directions 1
Magdy Selim, MD, PhD

2. Neuroimaging of the Acute Stroke Patient 3
William A. Copen, MD, and Michael H. Lev, MD

3. Intravenous Thrombolysis 39
Sherry H.-Y. Chou, MD, and Eric E. Smith, MD, MPH, FRCPC

4. Endovascular Approaches to Acute Stroke 63
Raul G. Nogueira, MD, Guilherme C. Dabus, MD, Joshua A. Hirsch, MD, and Lee H. Schwamm, MD

5. Nonthrombolytic Acute Stroke Therapies 97
Aneesh B. Singhal, MD, Larami MacKenzie, MD, and Joshua M. Levine, MD

6. Surgical Management of Acute Stroke Patients 123
Alim P. Mitha, MD, Carlos E. Sanchez, MD, and Christopher S. Ogilvy, MD

7. Antithrombotic Therapy for Acute Stroke 137
Orla Sheehan, MD, BAO, BCh, MRCPI, and Peter Kelly, MD, MS, FRCPI

8. Intensive Care Management of Acute Ischemic Stroke 163
Kevin N. Sheth, MD, and David M. Greer, MD, MA

9. Evaluation of Acute Stroke Etiologies 197
Karen L. Furie, MD, MPH, Michael H. Lev, MD, Walter J. Koroshetz, MD, and David M. Greer, MD, MA

10. TeleStroke: Application of Telemedicine in Acute Ischemic Stroke 213
Eric S. Rosenthal, MD, and Lee H. Schwamm, MD

Index 233

"The authors undoubtedly mastered the literature on their subject and may share a significant clinical experience…" (Journal of the American Medical Association, April 23, 2008)

"Great reference, with clear reviews of all the major clinical acute stroke topics.... Ideal information tool for someone needing to make a relatively up-to-date presentation." (Journal of the American Medical Association, May 2008)