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Posttraumatic Stress Disorder: From Neurobiology to Treatment




Posttraumatic Stress Disorder: From Neurobiology to Treatment

J. Douglas Bremner

ISBN: 978-1-118-35612-8 February 2016 Wiley-Blackwell 440 Pages



Posttraumatic Stress Disorder: From Neurobiology to Treatment presents a comprehensive look at this key neuropsychiatric disorder. The text examines the neurobiological basis of post-traumatic stress and how our understanding of the basic elements of the disease have informed and been translated into new and existing treatment options.

The book begins with a section on animal models in posttraumatic stress disorder research, which has served as the basis of much of our neurobiological information. Chapters then delve into applications of the clinical neuroscience of posttraumatic stress disorder. The final part of the books explores treatments and how our basic and clinical research is now being converted into treatment.

Taking a unique basic science to translational intervention approach, Posttraumatic Stress Disorder: From Neurobiology to Treatment is an invaluable resource for researchers, students and clinicians dealing with this complex disorder.

List of contributors vii

Introduction xi

Section I: Preclinical sciences of stress

1 Posttraumatic stress disorder: from neurobiology to clinical presentation 3
Arieh Y. Shalev & J. Douglas Bremner

2 The epidemiology of posttraumatic stress disorder in children and adolescents: a critical review 27
Leah A. McGuire

3 Early life stress and development: preclinical science 61
Dora B. Guzman, Brittany Howell & Mar Sanchez

4 Amygdala contributions to fear and safety conditioning: insights into PTSD from an animal model across development 81
Christopher Cain & Regina Sullivan

5 Preclinical evidence for benzodiazepine receptor involvement in the pathophysiology of PTSD comorbid substance abuse and alcoholism 105
Robert Drugan, Nathaniel P. Stafford & Timothy A. Warner

6 Psychosocial predator stress model of PTSD based on clinically relevant risk factors for trauma-induced psychopathology 125
Phillip R. Zoladz & David Diamond

7 Coping with stress in wild birds – the evolutionary foundations of stress responses 145
Molly J. Dickens & Michael Romero

8 Stress fear and memory in healthy individuals 159
Christian J. Merz, Bernet M. Elzinga & Lars Schwabe

Section II: Neurobiology of PTSD

9 Neurotransmitter neurohormonal and neuropeptidal function in stress and PTSD 181
J. Douglas Bremner & Brad Pearce

10 Genomics of PTSD 233
Anthony S. Zannas, Elisabeth Binder & Divya Mehta

11 Cortisol and the Hypothalamic–Pituitary–Adrenal Axis in PTSD 265
Amy Lehrner, Nicolaos Daskalakis & Rachel Yehuda

12 Neuroimaging of PTSD 291
Carolina Campanella & J. Douglas Bremner

Section III: PTSD and co-occuring conditions

13 PTSD and mild traumatic brain injury 321
J. Douglas Bremner

14 Stress-related psychopathology and pain 345
Sarah C. Reitz, Karl-Juergen Bär & Christian Schmahl

15 Stress and health 361
Viola Vaccarino, Emeran Mayer & J. Douglas Bremner

Section IV: PTSD: From neurobiology to treatment

16 Pharmacotherapy for PTSD: effects on PTSD symptoms and the brain 389
Lori Davis, Mark Hamner & J. Douglas Bremner

17 Effects of psychotherapy for psychological trauma on PTSD symptoms and the brain 413
J. Douglas Bremner & Carolina Campanella

Index 421