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Comprehensive Organic Transformations, A Guide to Functional Group Preparations, Two Volume Set, 2nd Edition

Comprehensive Organic Transformations, A Guide to Functional Group Preparations, Two Volume Set, 2nd Edition

Richard C. Larock

ISBN: 978-1-118-03758-4 December 2010 2640 Pages


In Stock




This long-awaited, greatly-expanded new edition of a best-selling guide offers an encyclopedic and systematic collection of useful synthetic methodology, including tens of thousands of reactions and synthetic transformations. The first edition has been reviewed in the professional journals as "clearly...the first choice for researchers seeking information on synthetic transformations." And as "useful to anyone who must do organic synthesis, especially those whose focus is not strictly organic chemistry. It provides a...clear road map to the synthetic literature and should be kept within easy reach of the chemist's desk."
Literature Abbreviations.

Chemical Abbreviations.


General References.

1. Reduction.

2. Coupling Reactions.

3. Friedel-Crafts and Related Alkylation Reactions.

4. Ring-Forming Reactions.

5. Aromization.


General References.

1. Isomerization of Alkenes.

2. Elimination.

3. Alkylidenation of Carbonyl and Related Compounds.

4. Wittig and Related Reactions.

5. Metal-Promoted Coupling Reactions.

6. Arene, Alkyne and Diene Addition Reactions.

7. Dienes and Polyenes.

8. Diels-Alder Reactions.

9. Cyclization, Annulation and Related Reactions.

10. Miscellaneous Reactions.


General References.

1. Isomerization.

2. Elimination Reactions.

3. Wittig and Related Approaches.

4. Alkylation, Alkenylation and Arylation of Alkynes and Allenes.


General References.

1. Halogenation of Hydrocarbons.

2. Aromatic Halogenation.

3. Halogenation of Alkenes.

4. Halogenation of Alkynes.

5. Interconversion of Halides.

6. Halogenation of Nitrogen Compounds.

7. Halogenation of Ethers.

8. Halogenation of Alcohols.

9. Halogenation off Phenols.

10. Halogenation of Sulfur and Selenium Compounds.

11. Halogenation of Carbonyl and Related Compounds.

12. Halodecarboxylation and Decarbonylation of Acids and Derivatives.

13. Halogenation of Organometallics.


General References.

1. From Alkanes.

2. From Arenes.

3. From Alkenes, Dienes and Alkynes.

4. From Alkyl and Aryl Halides or Sulfonates.

5. From Other Amines and Derivatives.

6. From Azides.

7. From Nitro Compounds.

8. Heteroatom and Metal Displacement.

9. From Ethers, Alcohols and Derivatives.

10. From Aldehydes, Ketones and Derivatives.

11. From Carboxylic Acids and Derivatives.

12. From Nitriles.

13. From Isonitriles.


General References.

1 From Other Ethers.

2. Alkylation of Alcohols and Phenols.

3. Alkanes, Arene, Alkene and Alkyne Additions and Substitutions.

4. Acetal, Carbonyl and Ortho Ester Conversions.

5. Miscellaneous Reactions.


General References.

1. Resolution.

2. Alcohols Transposition.

3. Substitution.

4. Oxidation.

5. Alkene, Diene and Alkyne Additions.

6. Organoboranes.

7. Ether Cleavage.

8. Reduction.

9. Alkylation of Carbonyl Compounds.

10. Miscellaneous Reactions.


General References.

1. Carbonyl Transportation.

2. Oxidation.

3. Reduction of Phenols, Carboxylic Acids and Derivatives, and Nitriles.

4. Rearrangements.

5. Condensation Reactions.

6. Cyclization and Annulation Reactions.

7. Carbonylation and Related Reactions.

8. Electrophilic Acylation.

9. Nucleophilic Acylation.

10. Sulfur, Selenium and Tellurium Reagents.

11. Heterocycles.

12. Carbonyl Homologation.

13. Alkylation and Acylation of Aldehydes, Ketones and Their Derivatives.

14. Alkylation of α and ß- Substituted Carbonyl Compounds.

15. 1,4-Addition to α,ß -Unsaturated Carbonyl Compounds and Derivatives.

16. Miscelaneous Reactions.


General References.

1. Oxidation, Substitution and Addition.

2. Reduction.

3. Carbonylation, Carboxylation and Related Reactions.

4. Carbonyl Homologation and Degradation.

5. Alkylation, Acylation and Substitution of Nitriles, Carboxylic Acids and Derivatives.

6. Conjugate Addition to ß,ß-Unsaturated Nitriles, carboxylic Acids and Derivatives.

7. Rearrangements.

8. Lactone and Lactam Formation.

9. Interconversion of Nitriles, Crboxylic Acids and Derivatives.

10. Miscellaneous Reactions.

Transformation Index.

"...this book is a wealth of synthetic chemical information." (Pharmaceutical Development & Technology, February 2005)

"...makes available at one's fingertips a wealth of information concerning a broad range of reaction types." (Angewandte Chemie)

"This edition covers 39 new journals and numerous additional reviews and books from 1988-95." (SciTech Book News, March 2001)

" indispensable reference work for designing and carrying out modern organic chemical synthesis.... It is amazing that so much information is contained in a single volume that is arranged in a logical and easy to use fashion." (Analytical Biochemistry, Vol. 294, 2001)

"...the book is undoubtedly still of great value and every chemist working in the area of synthesis should have it within reach in the laboratory." (Angewandte Chemie - International Edition, 3rd November 2000)

" outstanding work of reference...and will be an essential purchase for all synthetic organic chemists in academe and industry." (Natural Products Reports, Vol 17, 2000)

"This new edition is an invaluable resource.... This reference is a 'must have' addition to the library of any practicing synthetic chemist in the pharmaceutical sciences." (Pharmaceutical Research, Vol. 18, No. 9, September 2001)