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Somatostatin Analogues: From Research to Clinical Practice


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Featuring chapters from specialists in endocrinology, physiology, pathology, and nuclear medicine, this book provides a multidisciplinary approach to a wide variety of issues concerning somatostatin and its analogues. The book:

  • Provides the most up-to-date coverage of somatostatin analog use in diagnostic and therapy
  • Integrating the specialties of endocrinology, physiology, pathology, and nuclear medicine, providing the multidisciplinary approach to the topic
  • Focuses on future applications, novel compounds, and areas for further research
  • Covers topics by authors who are renowned experts and researchers in the field

Contributors viii

Preface xii

Acknowledgements xv

1 Somatostatin: The History of Discovery 1
Malgorzata TrofimiukMüldner and Alicja HubalewskaDydejczyk

2 Physiology of Endogenous Somatostatin Family: Somatostatin Receptor Subtypes, Secretion, Function and Regulation, and Organ Specific Distribution 6
Marily Theodoropoulou

3 Somatostatin Receptors in Malignancies and Other Pathologies 21
Marco Volante, Adele Cassenti, Ida Rapa, Luisella Righi, and Mauro Papotti

4 The Use of Radiolabeled Somatostatin Analogue in Medical Diagnosis: Introduction 31
Alberto Signore

4.1 Somatostatin Receptor Scintigraphy‐SPECT 35
Renata Mikołajczak and Alberto Signore

4.2 Molecular Imaging of Somatostatin Receptor‐Positive Tumors Using PET/CT 55

Richard P. Baum and Harshad R. Kulkarni
4.3 Other Radiopharmaceuticals for Imaging GEP‐NET 75
Klaas Pieter Koopmans, Rudi A. Dierckx, Philip H. Elsinga, Thera P. Links, Ido P. Kema, Helle-Brit Fiebrich, Annemieke M.E. Walekamp, Elisabeth G.E. de Vries, and Adrienne H. Brouwers

4.4 The Place of Somatostatin Receptor Scintigraphy in Clinical Setting: Introduction 86
Alicja HubalewskaDydejczyk

4.4.1 Somatostatin Receptor Scintigraphy in Management of Patients with Neuroendocrine Neoplasms 90
Anna SowaStaszczak, Agnieszka Stefańska, Agata JabrockaHybel, and Alicja HubalewskaDydejczyk

4.4.2 The Place of Somatostatin Receptor Scintigraphy and Other Functional Imaging Modalities in the Setting of Pheochromocytoma and Paraganglioma 112
Alicja HubalewskaDydejczyk, Henri J.L.M. Timmers, and Malgorzata TrofimiukMüldner

4.4.3 Somatostatin Receptor Scintigraphy in Medullary Thyroid Cancer 127
Anouk N.A. van der HorstSchrivers, Adrienne H. Brouwers, and Thera P. Links

4.4.4 Somatostatin Receptor Scintigraphy in Other Tumors Imaging 135
Malgorzata TrofimiukMüldner and Alicja HubalewskaDydejczyk

4.4.5 Somatostatin Receptor Scintigraphy in Inflammation and Infection Imaging 153
Alberto Signore, Kelly Luz Anzola Fuentes, and Marco Chianelli

5 Somatostatin Analogues in Pharmacotherapy: Introduction 164
Wouter W. de Herder

5.1 Somatostatin Analogues in Pharmacotherapy 166
Wouter W. de Herder

5.2 Pituitary Tumor Treatment with Somatostatin Analogues 169
Alicja Hubalewska-Dydejczyk, Aleksandra Gilis-Januszewska, and Malgorzata Trofimiuk-Müldner

5.3 Somatostatin Analogues in Pharmacotherapy of Gastroenteropancreatic Neuroendocrine Tumors 189
Frédérique Maire and Philippe Ruszniewski

5.4 Somatostatin Analogue Use in Other than Endocrine Tumor Indications 198
Aleksandra GilisJanuszewska, Malgorzata TrofimiukMüldner, Agata JabrockaHybel,, and Dorota Pach

6 Peptide Receptor Radionuclide Therapy Using Radiolabeled Somatostatin Analogues: An Introduction 207
John Buscombe

6.1 Somatostatin Analogues and Radionuclides Used in Therapy 214
Esther I. van Vliet, Boen L.R. Kam, Jaap J.M. Teunissen, Marion de Jong, Eric P. Krenning, and Dik J. Kwekkeboom

6.2 PRRT Dosimetry 230
Mark Konijnenberg

6.3 Peptide Receptor Radionuclide Therapy (PRRT): Clinical Application 252
Lisa Bodei, and Giovanni Paganelli

6.4 Duo‐PRRT of Neuroendocrine Tumors Using Concurrent and Sequential Administration of Y‐90‐ and Lu‐177‐Labeled Somatostatin Analogues 264
Richard P. Baum and Harshad R. Kulkarni

6.5 N onsystemic Treatment of Liver Metastases from Neuroendocrine Tumor 273
Daniel Putzer, Gerlig Widmann, Dietmar Waitz, Werner Jaschke, and Irene J. Virgolini

6.6 Peptide Receptor Radionuclide Therapy: Other Indications 282
Agnieszka Stefańska, Alicja HubalewskaDydejczyk, Agata JabrockaHybel, and Anna SowaStaszczak

7 Somatostatin Analogs: Future Perspectives and Preclinical Studies—Pansomatostatins 291
Aikaterini Tatsi Berthold A. Nock, Theodosia Maina, and Marion de Jong

8 Radiolabeled Somatostatin Receptor Antagonists 305
Melpomeni Fani and Helmut R. Maecke

9 Cortistatins and Dopastatins 321
Manuela Albertelli and Diego Ferone

Index 000