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Growth Factors as Drugs for Neurological and Sensory Disorders




Growth Factors as Drugs for Neurological and Sensory Disorders

Gregory R. Bock (Editor), Jamie A. Goode (Editor)

ISBN: 978-0-470-51487-0 April 2008 264 Pages



Degeneration of sensory receptors or of the nerves innervating them leads to a sensory deficit. Various strategies have been tried for promoting regrowth of sensory receptors, particularly in the eye and ear. The latest data from experimental studies in animals are presented in the book including applications of BDNF and CNTF in the eye and epidermal growth factor in the ear.
Partial table of contents:

Motor Neuron Disease and Model Systems: Aetiologies, Mechanisms and Therapies (D. Price, et al.).

Potential Utility of rhIGF-1 in Neuromuscular and/or Degenerative Disease (J. Vaught, et al.).

Development of Neurotrophic Factor Therapy for Alzheimer's Disease (F. Hefti, et al.).

Somatic Gene Therapy for Nervous System Disease (M. Tuszynski & F. Gage).

Neurotrophic Factors in the Treatment of Peripheral Neuropathy (S. Apfel & J. Kessler).

Growth Factors in the Treatment of Degenerative Retinal Disorders (T. Reh, et al.).

Growth Factors as Potential Drugs for the Sensory Epithelia of the Ear (J. Corwin, et al.).

The Problems of Delivering Neuroactive Molecules to the CNS (S. Tan & P. Aebischer).

Closing Remarks (J. Kessler).