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Amyloid Proteins: The Beta Sheet Conformation and Disease

Amyloid Proteins: The Beta Sheet Conformation and Disease

Jean D. Sipe (Editor)

ISBN: 978-3-527-61934-4 January 2008 799 Pages

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A first-stop reference on proteins associated with amyloidosis.
This book is the first to present a systematic overview of all known fibril-forming proteins, including their biochemical characteristics and pathophysiology. It considers the clinically recognized amyloid proteins that are known to be associated with the amyloid protein folding disorders, dealing with their common structural and thermodynamic features that lead to amyloid fibril formation and disease. Emphasis is on the thermodynamics of protein folding, the structure and physiologic effects of common oligomeric and subfibrillar intermediates and the influence of the extracellular matrix and cellular trafficking and metabolism on the genesis and catabolism of beta pleated sheet proteins.
The chapters on specific amyloid proteins all follow a common structure, allowing quick access to the desired biochemical and medical data, making this an invaluable tool for clinicians and researchers alike.

Volume 1

Preface XXI

List of Contributors XXIII

Part I Overview of Amyloidosis and Amyloid Proteins

1 Amyloidosis and Amyloid Proteins: Brief History and Definitions 3
Per Westermark

2 Anatomic and Clinical Clues to In Vivo Mechanisms of Amyloidogenesis 29
Vittorio Bellotti, Laura Obici, Robert Kisilevsky and Giampaolo Merlini

Part II Protein Structure and the Beta Pleated Sheet Conformation

3 The β-pleated Sheet Conformation and Protein Folding: A Brief History 49
Jean D. Sipe

Part III Protein Folding, Unfolding and Refolding

4 Thermodynamics and Protein Folding 65
Ilia V Baskakov

5 Role of Post-translational Chemical Modifications in Amyloid Fibril Formation 81
Melanie R. Nilsson

6 Lipid Modulators of Protein Misfolding and Aggregation 111
Christopher A. MacRaild and Geoffrey J. Howlett

7 Extracellular Matrix Heparan Sulfate Proteoglycans 131
Peter J. Neame and John T. Gallagher

8 Serum Amyloid P Component 169
David C. Kilpatrick

9 Serum amyloid P Component – Structural Features and Amyloid Recognition 189
S. P. Wood and A. R. Coker

10 Apolipoprotein E: Structural and Functional Interactions with Amyloid β 211
W. Blaine Stine Jr. and Mary Jo LaDu

Part IV Pathway to Amyloid Fibril Formation

11 Pathways to Amyloid Fibril Formation: Partially Folded Intermediates in the Fibrillation of Natively Unfolded Proteins 247
Vladimir N. Uversky and Anthony L. Fink

12 Structural Intermediates of Globular Proteins as Precursors to Amyloid Formation 275
Daniel F. Moriarty and Wilfredo Colón

13 Computational Approaches and Tools for Establishing Structural Models for Short Amyloid-forming Peptides 301
Nurit Haspel, David Zanuy, Hui-Hsu (Gavin) Tsai, Buyong Ma, Haim Wolfson and Ruth Nussinov

Part V Pathophysiology of Amyloid Fibril Formation

14 Oligomers and Cellular Toxicity 319
Bruce Kagan

15 The Future of Molecular Diagnostics and Targeted Therapeutics in the Amyloidoses 343
David C. Seldin

16 Brain Dysfunction Associated with Amyloid Fibrils and Other Aggregated Proteins 355
Giorgio Giaccone, Mario Salmona, Fabrizio Tagliavini and Gianluigi Forloni

Volume 2

Part VI Amyloid Proteins Brain 385

17 The Amyloid β Protein 385
Noel D. Lazo, Samir K. Maji, Erica A. Fradinger, Gal Bitan and David B. Teplow

18 Prion Protein 493
Philippe Derreumaux

19 Familial British and Danish Dementias 515
Jorge Ghiso, Agueda Rostagno, Yasushi Tomidokoro, Tammaryn Lashley, Janice L. Holton, Gordon Plant, Tamas Revesz and Blas Frangione

Systemic 527

20 Immunoglobulin 527
Fred J. Stevens

21 Transthyretin 571
Ana Margarida Damas and Maria João Saraiva

22 High-Density Lipoprotein Amyloid Proteins 589
Barbara Kluve-Beckerman

23 Gelsolin 625
Hadar Benyamini, Kannan Gunasekaran, Haim Wolfson and Ruth Nussinov

24 Lysozyme 635
Mireille Dumoulin, Vittorio Bellotti and Christopher M. Dobson

25 Fibrinogen 657
Gilles Grateau and Marc Delpech

26 β2-Microglobulin 667
Thomas R. Jahn and Sheena E. Radford

27 Cystatin C 697
Mariusz Jaskolski and Anders Grubb

Hormone 723

28 Endocrine Amyloid 723
Gunilla T. Westermark

Glossary of Terms 755

Subject Index 759

"Die Fulle und Dichte an Informationen in diesem gut 1.100 Seiten starken Werk ist enorm. Es ist daher ein Muss fur alle Experten. Allerdings steht mit diesen beiden Banden nun auch eine hervorragende Quelle fur all diejenigen zur Verfugung, die sich informieren oder in das Gebiet tiefer einsteigen wollen."
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