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The Liver: Biology and Pathobiology, 6th Edition




The Liver: Biology and Pathobiology, 6th Edition

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The sixth edition of this classic book retains its traditional strength of relating molecular physiology to understanding disease pathology and treatment as it explores the current state and future direction of hepatology.

The volume is fully revised throughout with 70 new chapters. As in previous editions, a section called Horizons summarizes advances of extraordinary nature in areas expected to have a substantial impact on hepatology.


List of Contributors



Part One: Introduction

1 Organizational Principles of the Liver
Peter Nagy, Snorri S. Thorgeirsson, Joe W. Grisham

2 Embryonic Development of the Liver
Kenneth S. Zaret, Roque Bort, Stephen A. Duncan

Part Two: The Cells

Section A: Cell Biology of the Liver

3 Cytoskeletal Motors: Structure and Function in Hepatocytes
Mukesh Kumar, Arnab Gupta, Roop Mallik

4 Hepatocyte Surface Polarity
Anne Muesch, Irwin Arias

5 Primary Cilia
Carolyn M. Ott

6 Endocytosis in Liver Function and Pathology
Micah B. Schott, Barbara Schroeder, Mark A. McNiven

7 The Hepatocellular Secretory Pathway
Catherine Jackson, Mark A. McNiven

8 Mitochondrial Function, Dynamics, and Quality Control
Marc Liesa, Ilan Benador, Nathanael Miller, Orian S. Shirihai

9 Nuclear Pore Complex
Michelle A. Veronin, Joseph S. Glavy

10 Protein Maturation and Processing at the Endoplasmic Reticulum
Ramanujan S. Hegde

11 Protein Degradation and the Lysosomal System
Susmita Kaushik, Ana Maria Cuervo

12 Peroxisome Assembly, Degradation, and Disease
Rong Hua, Peter K. Kim

13 Organelle–Organelle Contacts: Origins and Functions
Uri Manor

14 Gap and Tight Junctions in Liver: Structure, Function and Pathology
John W. Murray, David C. Spray

15 Ribosome Assembly and its Role in Cell Growth and Proliferation in the Liver
Katherine I. Farley-Barnes, Susan J. Baserga

16 miRNAs and Hepatocellular Carcinoma
Yusuke Yamamoto, Isaku Kohama, Takahiro Ochiya

17 Hepatocyte Apoptosis: Mechanisms and relevance in liver diseases
Gregory J. Gores, Harmeet Malhi

Section B: The Hepatocyte

18 Copper Metabolism and the Liver\
Cynthia Abou Zeid, Ling Yi, Stephen G. Kaler

19 The Central Role of the Liver in Iron Storage and Regulation of Systemic Iron Homeostasis
Tracey A. Rouault, Victor Gordeuk, Gregory J. Anderson

20 Disorders of Bilirubin Metabolism
Namita Roy Chowdhury, Yanfeng Li, Jayanta Roy Chowdhury

21 Hepatic Lipid Droplets in Liver Function and Disease
Douglas G. Mashek, Wenqi Cui, Linshan Shang, Charles P. Najt

22 Lipoprotein Metabolism and Cholesterol Balance
Mariana Acuña-Aravena, David E. Cohen

Section C: Transporters, Bile Acids, and Cholestasis

23 Bile Acids Metabolism in Health and Disease: An update
Tiangang Li, John Y. L. Chiang

24 TGR5 (GPBAR1) in the Liver
Verena Keitel, Christoph G.W. Gertzen, Lina Spomer, Holger Gohlke, Dieter Häussinger

25 Bile Acids as Signaling Molecules
Thierry Claudel, Michael Trauner

26 Hepatic Adenosine Triphosphate-Dependent (ABC) Transporters and Their Role in Physiology
Peter L.M. Jansen

27 Basolateral Plasma Membrane Organic Anion Transporters
M. Sawkat Anwer, Allan W. Wolkoff

28 Hepatic Nuclear Receptors
Raymond E. Soccio

29 Molecular Cholestasis
Paul Gissen, Richard J. Thompson

30 Pathophysiologic Basis for Alternative Therapies for Cholestasis
Claudia D. Fuchs, Emina Halilbasic, Michael Trauner

31 Adaptive Regulation of Hepatocyte Transporters in Cholestasis
James L. Boyer

Section D: Non-Hepatocyte Cells

32 Cholangiocyte Biology and Pathobiology
Massimiliano Cadamuro, Romina Fiorotto, Mario Strazzabosco

33 Polycystic Liver Diseases: Genetics, Mechanisms, and Therapies
Tatyana Masyuk, Anatoliy Masyuk, Nicholas LaRusso

34 The Liver Sinusoidal Endothelial Cell: Basic Biology and Pathobiology
Karen K. Sørensen, Bård Smedsrød

35 Fenestrations in the Liver Sinusoidal Endothelial Cell
Victoria C Cogger, Nicholas J Hunt, David G Le Couteur

36 Stellate Cells and Fibrosis
Youngmin A. Lee, Scott L. Friedman

Part 3: Functions of the Liver

Section A: Metabolic Functions

37 Nonalcoholic Fatty Liver Disease and Insulin Resistance
Max C. Petersen, Varman T. Samuel, Kitt Falk Petersen, Gerald I. Shulman

38 AMPK: Central regulator of glucose and lipid metabolism and target of type 2 diabetes therapeutics
Daniel Garcia, Maria M. Mihaylova, Reuben J. Shaw

39 Insulin-mediated PI3K and AKT Signaling
Jeffrey E. Pessin, Hyokjoon Kwon

40 Ca2+ Signaling in the Liver
Mateus T. Guerra, M. Fatima Leite, Michael H. Nathanson

41 Clinical Genomics of NAFLD
Frank Lammert

Section B: Liver Growth and Regeneration

42 Stem Cell-Fueled Maturational Lineages in Hepatic and Pancreatic Organogenesis
Wencheng Zhang, Amanda Allen, Eliane Wauthier, Xianwen Yi, Homayoun Hani, Praveen Sethupathy, David Gerber, Vincenzo Cardinale, Guido Carpino, Juan Dominguez-Bendala, Giacomo Lanzoni, Domenico Alvaro, Eugenio Gaudio, Lola Reid

43 Developmental Morphogens and Adult Liver Repair
 Mariana Machado, Anna Mae Diehl

44 Liver Repopulation by Cell Transplantation and the Role of Stem Cells in Liver Biology
David A. Shafritz, Markus Grompe

45 Liver Regeneration
George K. Michalopoulos

46 β-Catenin Signaling
Satdarshan P. S. Monga

47 Polyploidy in Liver Function, Mitochondrial Metabolism and Cancer
Evan R. Delgado, Elizabeth C. Stahl, Nairita Roy, Patrick D. Wilkinson, Andrew W. Duncan

Part 4: Pathobiology of Liver Disease

48 Hepatic Encephalopathy
Roger F. Butterworth

49 The Kidney in Liver Disease
Moshe Levi, Shogo Takahashi, Xiaoxin X. Wang, Marilyn E. Levi

50 Alpha-1 Antitrypsin Deficiency
David A. Rudnick, David H. Perlmutter

51 Pathophysiology of Portal Hypertension
Roberto J. Groszman, Yasuko Iwakiri

52 Nonalcoholic Fatty Liver Disease: Mechanisms and treatment
Yaron Rotman, Devika Kapuria

53 Alcoholic Liver Disease
Bin Gao, Xiaogang Xiang, Lorenzo Leggio, George F. Koob

54 Drug-induced Liver Injury
Lily Dara, Neil Kaplowitz

55 Oxidative Stress and Inflammation in the Liver
John J. Lemasters, Hartmut Jaeschke

56 The Role of Bile Acid-mediated Inflammation in Cholestatic Liver Injury
Shi-Ying Cai, Man Li, James L. Boyer

57 Toll-like Receptors in Liver Disease
So Yeon Kim, Ekihiro Seki

Part 5: Liver Cancer

58 Experimental Models of Liver Cancer: Genomic assessment of experimental models
Sun Young Yim, Jae-Jun Shim, Bo Hwa Sohn, Ju-Seog Lee

59 Epidemiology of Liver Cancer
Hashem B. El-Serag

60 Mutations and Genomic Alterations in Liver Cancer
Jessica Zucman-Rossi, Jean-Charles Nault

61 Treatment of Liver Cancer
Tim F. Greten

Part 6: Hepatitis

62 Molecular Biology of Hepatitis Viruses
Christoph Seeger, William S. Mason, Michael M.C. Lai

63 Immune Mechanisms of Viral Clearance and Disease Pathogenesis during Viral Hepatitis
Carlo Ferrari, Valeria Barili, Stefania Varchetta, Mario U. Mondelli

64 Clinical Implications of the Molecular Biology of Hepatitis B Virus
Timothy M. Block, Ju-Tao Guo, W. Thomas London

65 Viral Escape Mechanisms in Hepatitis C and the Clinical Consequences of Persistent Infection
Marc G. Ghany, Christopher M. Walker, Patrizia Farci

66 Tracking Hepatitis C Virus Interactions with the Hepatic Lipid Metabolism: A hitchhiker´s guide to solve remaining translational research challenges in hepatitis C
Thomas Pietschmann, Gabrielle Vieyres

67 Nucleoside Antiviral Agents for HCV: What’s left to do?
Franck Amblard, Seema Mengshetti, Junxing Shi, Sijia Tao, Leda Bassit, Raymond F. Schinazi

68 Hepatitis E Virus: An emerging zoonotic virus causing acute and chronic liver disease
Xiang-Jin Meng

69 Biological Principles and Clinical Issues Underlying Liver Transplantation for Viral-Induced End-stage Liver Disease in the Era of Highly Effective Direct-Acting Antiviral Agents
Michael S. Kriss, James R. Burton, Jr., Hugo R. Rosen

70 Time for the Elimination of Hepatitis C Virus as a Global Health Threat
John W. Ward, Alan R. Hinman, Harvey J. Alter

Part 7: Horizons

H1 Genome Editing by Targeted Nucleases and the CRISPR/Cas Revolution
Shawn M. Burgess

H2 Imaging Cellular Proteins and Structures: Smaller, Brighter, and Faster
Aubrey V. Weigel, Erik Lee Snapp

H3 Liver-directed Gene Therapy
Patrik Asp, Chandan Guha, Namita Roy Chowdhury, Jayanta Roy Chowdhury

H4 Telomeres and Telomerase in Liver Generation and Cirrhosis
Sonja C. Schätzlein, K. Lenhard Rudolph

H5 Toxins and Biliary Atresia
Michael Pack, Rebecca G. Wells

H6 The Dual Role of ABC Transporters in Drug Metabolism and Resistance to Chemotherapy
Jean-Pierre Gillet, Marielle Boonen, Michel Jadot, Michael M. Gottesman

H7 Stem-cell-derived Liver Cells: From model system to therapy
Helmuth Gehart, Hans Clevers

H8 Extracellular Vesicles and Exosomes: Biology and pathobiology
Gyongyi Szabo, Fatemeh Momen-Heravi

H9 Integrated Technologies for Liver Tissue Engineering
Tiffany N. Vo, Amanda X. Chen, Quinton B. Smith, Arnav Chhabra, Sangeeta N. Bhatia

H10 Stem Cells, IPS Cells, Reprogramming: Therapy promise
Stephen A. Duncan

H11 Chromatin Regulation and Transcription Factor Cooperation in Liver Cells
Ido Goldstein

H12 Drug Interactions in the Liver
Guruprasad P. Aithal, Gerd A. Kullak-Ublick

H13 Metabolic Regulation of Hepatic Growth
Wolfram Goessling

H14 The Gut Microbiome and Liver Disease
Lexing Yu, Jasmohan S. Baja, Robert F. Schwabe

H15 Lineage Tracing: Efficient tools to determine the fate of hepatic cells in health and disease
Frédéric Lemaigre

H16 The Hepatocyte as a Household for Plasmodium Parasites
Vanessa Zuzarte-Luis, Maria M. Mota