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Organic Reactions Volume 100





Organic Reactions Volume 100

Scott E. Denmark (Editor-in-Chief)

ISBN: 978-1-119-45666-7 December 2019 750 Pages



Written by a "who is who" of leading organic chemists, this anniversary volume represent the Organic Reactions editors’ choice of the most important, ground-breaking and versatile reactions in current organic synthesis. The 18 reaction types selected for this volume include reactions for carbon-carbon bond formation, cross-coupling reactions, hydro- and halofunctionalizations, among many others.
In line with the successful recipe of the series, each chapter is focused on a single reaction, discussing its mechanism and stereochemistry, scope and limitations, applications to synthesis, comparison with other methods, and experimental procedures. Each chapter concludes with a tabular survey of selected key application examples, complete with reported reaction conditions and yields, to serve as a quick reference guide for synthesis planning.
The Negishi Cross-Coupling Reaction
Generation and Trapping of Functionalized Aryl and Heteroaryl Magnesium and Zinc Compounds
Copper-Catalyzed, Enantioselective Hydrofunctionalization of Alkenes
The Catalytic, Enantioselective Favorskii Reaction: In situ Formation of Metal Alkynylides and Their Additions to Aldehydes
Enantioselective Lithiation-Substitution of Nitrogen Containing Heterocycles
Catalytic, Enantioselective, Transfer Hydrogenation
Hydrofunctionalization of Alkenes by Hydrogen Atom Transfer
Carbon-Carbon Bond Formation by Metallophotoredox Catalysis
The Suzuki-Miyaura Cross-Coupling Reaction
ortho-directed C−H Alkylation of Substituted Benzenes
Catalytic, Enantioselective, CH Functionalization to form Carbon-Carbon Bonds
Catalytic, Enantioselective Fluorination Reactions
Enantioselective Halofunctionalization of Alkenes
Catalyzed Azide Alkyne Cycloadditions
Palladium Catalyzed C-N Coupling Reactions
Catalytic, Enantioselective Copper–Boron Additions to Alkenyl Groups
Catalytic Glycosylation
Transition Metal-Mediated and Metal Catalyzed Carbon-Fluorine Bond Formation