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Antibiotic Drug Resistance

José-Luis Capelo-Martínez (Editor), Gilberto Igrejas (Editor)

ISBN: 978-1-119-28252-5 September 2019 704 Pages

Description

This book presents a thorough and authoritative overview of the multifaceted field of antibiotic science – offering guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases. 

  • Provides readers with knowledge about the broad field of drug resistance
  • Offers guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases
  • Links strategies to analyze microbes to the development of new drugs, socioeconomic impacts to therapeutic strategies, and public policies to antibiotic-resistance-prevention strategies

List of Contributors

Preface

Part I: Current antibiotics and their mechanism of action

Chapter 1: Resistance to aminoglycosides: glycomics and the link to the Human gut microbiome

Chapter 2: Mechanisms of action and of resistance to quinolones

Chapter 3: Betalactams

Chapter 4: Glycopeptide antibiotics: Mechanism of action and recent developments

Chapter 5: Current macrolide antibiotics and their mechanisms of action

Part II: Mechanism of antibiotic resistance

Chapter 6: Impact of key and secondary drug resistance mutations on structure and activity of β-lactamases

Chapter 7: Acquired resistance from gene transfer

Chapter 8: Antimicrobial efflux pumps

Chapter 9: Bacterial persistence in biofilms and antibiotics: mechanisms involved

Part III: Socio-economical perspectives and impact of AR

Chapter 10: Sources of antibiotic resistance – zoonotic, human, environment

Chapter 11: Antibiotic Resistance – immunity, acquired resistance: Evolution of antimicrobial resistance among extended-spectrum β-lactamases and Carbapenemases in Klebsiella pneumoniae and Escherichia coli

Chapter 12: Prevalence of AR – world map: Overview of Extended-Spectrum-β-Lactamase and Carbapenemase -Producing Enterobacteriaceae in Food-Producing Animals in Europe. A Impact on Public Health?

Part IV: Therapeutic Strategy for overcoming AR

Chapter 13: AR mechanism based drug design

Chapter 14: Antibiotics from natural sources

Chapter 15: Bacteriophage proteins as antimicrobials to combat antibiotic resistance

Chapter 16: Antibiotics modification addressing resistance

Chapter 17: Sensitizing agents to restore antibiotic activity

Chapter 18: Repurposing antibiotics to treat resistant gram-negative pathogens

Chapter 19: Non-traditional medicines for treatment of AR

Chapter 20: Therapeutic options for treatment of infections by pathogenic biofilms

Part V: Strategies to prevent the spread of AR

Chapter 21: Rapid analytical methods to identify AR bacteria

Chapter 22: Effective methods for disinfection and sterilization

Chapter 23: Strategies to prevent the spread of antibiotic resistance: understanding the role of antibiotics in nature and their rational use

Part VI: Public policy

Chapter 24: Strategies reduce or eliminate resistant pathogen in the environment