Skip to main content

In Vitro Drug Release Testing of Special Dosage Forms





In Vitro Drug Release Testing of Special Dosage Forms

Nikoletta Fotaki (Editor), Sandra Klein (Editor)

ISBN: 978-1-118-34147-6 November 2019 288 Pages



Guides readers on the proper use of in vitro drug release methodologies in order to evaluate the performance of special dosage forms

In the last decade, the application of drug release testing has widened to a variety of novel/special dosage forms. In order to predict the in vivo behavior of such dosage forms, the design and development of the in vitro test methods need to take into account various aspects, including the dosage form design and the conditions at the site of application and the site of drug release. This unique book is the first to cover the field of in vitro release testing of special dosage forms in one volume. Featuring contributions from an international team of experts, it presents the state of the art of the use of in vitro drug release methodologies for assessing special dosage forms’ performances and describes the different techniques required for each one.

In Vitro Drug Release Testing of Special Dosage Forms covers the in vitro release testing of: lipid based oral formulations; chewable oral drug products; injectables; drug eluting stents; inhalation products; transdermal formulations; topical formulations; vaginal and rectal delivery systems and ophthalmics. The book concludes with a look at regulatory aspects. 

  • Covers both oral and non-oral dosage forms
  • Describes current regulatory conditions for in vitro drug release testing
  • Features contributions from well respected global experts in dissolution testing

In Vitro Drug Release Testing of Special Dosage Forms will find a place on the bookshelves of anyone working with special dosage forms, dissolution testing, drug formulation and delivery, pharmaceutics, and regulatory affairs.

Part I: Oral dosage forms

Chapter 1: Lipid based oral formulations
Murat Kilic1, Aikaterini Avzoti2, Jennifer Dressman1 and Christos Reppas2
1 Goethe University, Frankfurt/Main, Germany
2 National and Kapodistrian University of Athens, Greece

Chapter 2: Chewable oral drug products
Johannes Krämer, Jayachandar Gajendran, Alexis Guillot and Abdulwahab Barakat
PHAST Development GmbH & Co. KG, Konstanz, Germany

Part II: Non-oral dosage forms

Chapter 3: Injectables
Susan D´Souza
Sunovion Pharmaceuticals Inc, Marlborough, MA 01752, USA

Chapter 4: Drug eluting stents
Anne Seidlitz, University of Greifswald, Germany

Chapter 5: Inhalation products
Annalisa Mercuri1, Nikoletta Fotaki2*
1 The Aptuit Center for Drug Discovery & Development, Verona, Italy
2 Department of Pharmacy and Pharmacology, University of Bath, Bath, UK

Chapter 6: Topicals and transdermals
Kailas Thakker, Tergus Pharma LLC, Durham NC, USA

Chapter 7: Vaginal and intrauterine delivery systems
Sandra Klein, Katharina Tietz, University of Greifswald, Germany

Chapter 8: Rectal dosage forms
Sandra Klein, University of Greifswald, Germany

Chapter 9: Ophthalmic drug products
Christian Simroth-Loch1, Werner Weitschies1, Clive G. Wilson2
1 University of Greifswald, Germany
2 University of Strathclyde, Glasgow, UK

Chapter 10: Regulatory aspects
Vivian A. Gray
V. A. Gray Consulting, Inc, Hockessin, Delaware, USA