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Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery




Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery

Dev P. Arya

ISBN: 978-0-470-14966-9 August 2007 336 Pages



Advances that open new avenues in developing aminoglycoside antibiotics

During the last twenty years, there have been numerous advances in the understanding of the chemistry, biochemistry, and recognition of aminoglycosides. This has led to the development of novel antibiotics and opened up new therapeutic targets for intervention. This is the first book to provide a complete overview of recent advances in the field and explore their tremendous potential for drug discovery and rational drug design. With chapters written by one or more leading experts in their specialty areas, the book addresses the chemistry, biology, and toxicology of aminoglycosides.

Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery is a great resource for academic and industrial researchers in drug design and mechanism studies and for researchers studying antibiotic resistance, antibiotic design and synthesis, and the discovery of novel pharmaceuticals. It is also a valuable reference for graduate students in pharmacy, pharmaceutical science, biophysics, medicinal chemistry, and chemical biology.

Preface vii

Contributors ix

1. In the Beginning There Was Streptomycin 1
Julian Davies

2. The Biochemistry and Genetics of Aminoglycoside Producers 15
Wolfgang Piepersberg, Khaled M. Aboshanab, Heike Schmidt-Beißner, and Udo F. Wehmeier

3. Mechanisms of Aminoglycoside Antibiotic Resistance 119
Tushar Shakya and Gerard D. Wright

4. Design, Chemical Synthesis, and Antibacterial Activity of Kanamycin and Neomycin Class Aminoglycoside
Antibiotics 141
Jinhua Wang and Cheng-Wei Tom Chang

5. NMR Structural Studies of Aminoglycoside: RNA Interaction 181
R. Andrew Marshall and Joseph D. Puglisi

6. Structural Comparisons Between Prokaryotic and Eukaryotic Ribosomal Decoding A Sites Free and Complexed with Aminoglycosides 209
Jiro Kondo and Eric Westhof

7. Binding of Antibiotics to the Aminoacyl-tRNA Site of Bacterial Ribosome 225
Dale Kling, Christine Chow, and Shahriar Mobashery

8. Metalloaminoglycosides: Chemistry and Biological Relevance 235
Nikhil Gokhale, Anjali Patwardhan, and J. A. Cowan

9. Adverse Effects of Aminoglycoside Therapy 255
Andra E. Talaska and Jochen Schacht

10. Targeting HIV-1 RNA with Aminoglycoside Antibiotics and Their Derivatives 267
Lev Elson-Schwab and Yitzhak Tor

11. Novel Targets for Aminoglycosides 289
Dev P. Arya, Nicholas Shaw, and Hongjuan Xi

Index 315

"This is a 'must-have' text for anyone involved in AGA teaching or research. No better comprehensive treatise exists…" (Journal of Medicinal Chemistry, October 18, 2007)


"There is little doubt that this volume will be a tremendous resource for any investigator interested in the biochemistry of aminoglycosides." (Journal of the American Chemical Society, September 26, 2007)