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Evidence-Based Dermatology, 2nd Edition




Evidence-based Dermatology, Second Edition is a unique book in the field of clinical dermatology. Written and edited by some of the world’s leading experts in evidence-based dermatology, it takes a highly evidence-based approach to the treatment of all major and many of the less common skin conditions.

The toolbox at the beginning of the book explaining how to critically appraise different studies, along with the comprehensive reviewing and appraisal of evidence in the clinical chapters makes this book distinctive in its field as do the treatment recommendations which are based on the discussion of the best available evidence using a question-driven approach and a common structure on dealing with efficacy, drawbacks and implications for clinical practice.

Contributors, viii

Foreword, xiii

Preface, xv

Part I: The concept of evidence-based dermatology
Andrew Herxheimer, Editor

1. The field and its boundaries, 3
Luigi Naldi

2. The rationale for evidence-based dermatology, 8
Hywel Williams, Michael Bigby

3. The role of the consumer and the public in evidence-based dermatology, 14
Maxine Whitton, Andrew Herxheimer

4. The Cochrane Skin Group, 20
Tina Leonard, Finola Delamere, Dedee F. Murrell

Part II: The critical appraisal toolbox
Michael Bigby, Editor

5. Formulating well-built clinical questions, 29
Berthold Rzany, Michael Bigby

6. Finding the best evidence, 31
Michael Bigby, Rosamaria Corona

7. The hierarchy of evidence, 34
Michael Bigby

8. Appraising systematic reviews and meta-analyses, 38
Michael Bigby, Hywel Williams

9. How to critically appraise a randomized controlled trial, 44
Hywel Williams

10. How to assess the evidence concerning the safety of medical interventions, 52
Luigi Naldi

11. What makes a good case series? 56
Joerg Albrecht, Michael Bigby

12. What makes a good prevalence survey? 61
Magdalena Radulescu, Thomas Diepgen, Hywel Williams

13. Critical appraisal of pharmacoeconomic studies, 68
Laura K. DeLong, Suephy C. Chen

14. Applying the evidence back to the patient, 73
Hywel Williams

Part III: The evidence

Part IIIa: Common inflammatory skin diseases
Luigi Naldi, Editor

15. Acne vulgaris, 83
Avanta P. Collier, Scott R. Freeman, Robert P. Dellavalle

16. Papulopustular rosacea, 105
Alfredo Rebora

17. Perioral dermatitis, 111
Aditya K. Gupta

18. Hand eczema, 117
A. Marco van Coevorden, Thomas Diepgen, Pieter-Jan Coenraads

19. Atopic eczema, 128
Kim Thomas, Fiona Bath-Hextall, Jane Ravenscroft, Carolyn Charman, Hywel Williams

20. Seborrheic dermatitis, 164
Mauro Picardo, Norma Cameli

21. Psoriasis, 171
Luigi Naldi, Robert J.G. Chalmers

22. Lichen planus, 189
Laurence Le Cleach, Olivier Chosidow, Bernard Cribier

23. Acute urticaria, 197
Torsten Schäfer

24. Chronic urticaria, 202
Conrad Hauser, Philip Taramarcaz

Part IIIb: Skin cancer, moles, and photoaging
Hywel Williams, Editor

25. Primary prevention of skin cancer, 215
Ros Weston

26. Do sunscreens reduce the incidence of skin cancers? 226
Ros Weston

27. Cutaneous melanoma, 236
Dafydd Roberts, Thomas Crosby

28. Squamous cell carcinoma, 248
Nanette J. Liegeois, Su-Jean Seo, Suzanne Olbricht

29. Basal cell carcinoma, 256
Fiona Bath-Hextall, William Perkins

30. Primary cutaneous T-cell lymphoma, 272
Sean Whittaker

31. Actinic keratoses and Bowen's disease, 294
Aditya K. Gupta, Jenna E. Bowen, Elizabeth A. Cooper, Seaver L. Soon, Peterson Pierre, Suephy C. Chen

32. Kaposi's sarcoma, 315
Rosamaria Corona, Margaret F. Spittle, Russell N. Moule, Michael Bigby

33. Photoaging, 326
Miny Samuel, Jean-Paul Deslypere, Christopher E.M. Griffiths

34. Melanocytic nevi, 337
Paolo Carli, Camilla Salvini

Part IIIc: Infective skin diseases and exanthems
Hywel Williams and Thomas Diepgen, Editors

35. Local treatment for cutaneous warts, 347
Sam Gibbs

36. Impetigo, 354
Sander Koning, Lisette W.A. van Suijlekom-Smit, Johannes C. van der Wouden

37. Athlete 's foot, 358
Fay Crawford

38. Onychomycosis, 362
Aditya K. Gupta, Elizabeth A. Cooper

39. Tinea capitis, 386
Urbà González

40. Deep fungal infections, 397
Roderick J. Hay

41. Streptococcal cellulitis/erysipelas of the lower leg, 406
Neil H. Cox

42. Exanthematic reactions, 418
Sandra R. Knowles, Neil H. Shear

43. Herpes simplex, 428
Vera Mahler

44. Leprosy, 439
Shamez Ladhani, Weiya Zhang

45. Cutaneous leishmaniasis, 451
Urbà González, Mayda Delma Villalta Alvarez

Part IIId: Infestations
Berthold Rzany, Editor

46. Scabies, 463
Ian F. Burgess

47. Head lice, 471
Ian F. Burgess, Ciara S. Casey

48. Insect bites and stings, 478
Belen Lardizabal-Dofitas

Part IIIe: Disorders of pigmentation
Berthold Rzany, Editor

49. Vitiligo, 489
Juan Jorge Manriquez

50. Melasma, 497
Asad Salim, Mónica Rengifo-Pardo, Sam Vincent, Luis Gabriel Cuervo-Amore

Part IIIf: Hair problems
Berthold Rzany, Editor

51. Male and female androgenetic alopecia, 513
Hans Wolff

52. Alopecia areata, 518
Rod Sinclair, Yee Jen Tai

53. Evidence-based treatment of hirsutism, 527
Ulrike Blume-Peytavi, Natalie Garcia-Bartels

Part IIIg: Leg ulceration
Berthold Rzany, Editor

54. Venous ulcers, 539
Jonathan Kantor, David J. Margolis

Part IIIh: Other important skin disorders
Michael Bigby, Editor

55. Cutaneous lupus erythematosus, 549
Susan Jessop, David Whitelaw

56. Dermatomyositis, 559
David F. Fiorentino, Jeffrey P. Callen

57. Acquired subepidermal bullous diseases, 573
Gudula Kirtschig, Nonhlanhla P. Khumalo, Vanessa Venning, Fenella Wojnarowska

58. Pemphigus, 581
Brian R. Sperber, Linda K. Martin, Dedee F. Murrell, Victoria P. Werth

59. Cutaneous sarcoidosis, 595
Leonid Izikson, Joseph C. English III

60. Erythema multiforme, 608
Pierre-Dominique Ghislain, Jean-Claude Roujeau

61. Stevens-Johnson syndrome and toxic epidermal necrolysis, 613
Pierre-Dominique Ghislain, Jean-Claude Roujeau

62. Focal hyperhidrosis, 621
Berthold Rzany, Hendrik Zielke, Thomas Sycha, Peter Schnider

63. Polymorphic light eruption (PLE), 629
Robert S. Dawe, James Ferguson

64. Infantile hemangiomas and port-wine stains, 633
Kapila Batta, Sean W. Lanigan

65. Psychocutaneous disease, 643
Dennis Linder

66. Pruritus, 650
Elke Weisshaar, Malcolm W. Greaves

67. Other skin diseases for which trials exist, 671
Sinéad Langan, Hywel Williams

Part IV: The future of evidence-based dermatology
Luigi Naldi, Editor

68. Where do we go from here? 703
Hywel Williams

Additional chapters and resources are published on the book's web site (

“This reference text contains valuable and current information that could be read with benefit by dermatologists and other physicians interested in cutaneous medicine. It does belong in a well-stocked personal or reference library.” (JAMA, March 2009)

“This is a terrific book! All dermatologists should consider it required reading. The best designed studies, if they exist, are discussed in detail. This is a wonderful resource and should be used by anyone who considers himself/herself a relevant, educated, up-to-date dermatologist. I applaud the authors for their excellent efforts. If you aren't inclined to try to master the skills to evaluate all the studies, then just read this book. The authors have already done all the work for you.” (Doodys Book Reviews, December 2008)

The first truly evidence-based dermatology reference book

  • Increased patient focus
  • Three new chapters cover the delivery of best practice alongside eight new clinical chapters
  • Includes access to a dedicated website for chapter updates