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A Cell Biologist's Guide to Modeling and Bioinformatics



A Cell Biologist's Guide to Modeling and Bioinformatics

Raquell M. Holmes

ISBN: 978-0-470-13934-9 February 2008 224 Pages


A step-by-step guide to using computational tools to solve problems in cell biology

Combining expert discussion with examples that can be reproduced by the reader, this text introduces an array of informatics tools that are available for analyzing biological data and modeling cellular processes. You learn to fully leverage public databases and create your own computational models. All that you need is a working knowledge of algebra and cellular biology; the author provides all the other tools you need to understand the necessary statistical and mathematical methods.

Coverage is divided into two main categories:

Molecular sequence database chapters are dedicated to gaining an understanding of tools and strategies-including queries, alignment methods, and statistical significance measures-needed to improve searches for sequence similarity, protein families, and putative functional domains. Discussions of sequence alignments and biological database searching focus on publicly available resources used for background research and the characterization of novel gene products.

Modeling chapters take you through all the steps involved in creating a computational model for such basic research areas as cell cycle, calcium dynamics, and glycolysis. Each chapter introduces a new simulation tooland is based on published research. The combination creates a rich context for ongoing skill and knowledge development in modeling biological research systems.

Students and professional cell biologists can develop the basic skills needed to learn computational cell biology. This text, with its step-by-step instruction, enables you to test and develop your new bioinformatics and modeling skills. References are provided to help you take advantage of more advanced techniques, technologies, and training.

Book Overview ix

Acknowledgments xiii

1. Introduction 1

2. Sequence Alignments and Database Searches 9

3. Family-Domain Databases 35

4. Getting Started: Modeling 57

5. Modeling Metabolism 75

6. Cell Cycle 103

7. Calcium Dynamics 121

8. Advanced Computing 165

Glossary 189

Index 199

"A Cell Biologist's Guide to Modeling and Bioinformatics is well written, well illustrated…this volume is a must-read for any biologist who wants an introduction to quantitative methods.  It will also be a useful textbook for students." (The Quarterly Review of Biology, September 2008)
  • Includes brief primers in both computational sciences and cell biology
  • Does not assume any advanced mathematical training
  • Highlights currently available tools and principles related to cellular processes
  • Provides comprehensive resource list for additional information
  • Only available synthesis of bioinformatics as applied to cell and developmental biology
  • End-of-chapter problem sets with answers provided, as well as boxes highlighting key technology developments by experts in the field