Skip to main content

An Introduction to Pain and its relation to Nervous System Disorders

An Introduction to Pain and its relation to Nervous System Disorders

Anna A. Battaglia (Editor)

ISBN: 978-1-118-45596-8

Mar 2016

440 pages


Introduction to Pain and its relation to Nervous System Disorders provides an accessible overview of the latest developments in the science underpinning pain research, including, but not limited to, the physiological, pathological and psychological aspects. This unique book fills a gap in current literature by focussing on the intricate relationship between pain and human nervous system disorders such as Autism, Alzheimer Disease, Parkinson’s Disease, Depression and Multiple Sclerosis. This fully illustrated, colour handbook will help non-experts, including advanced undergraduate and new postgraduate students, become familiar with the current, wide-ranging areas of research that cover every aspect of the field from chronic and inflammatory pain to neuropathic pain and biopsychosocial models of pain, functional imaging and genetics.

Contributions from leading experts in neuroscience and psychiatry provide both factual information and critical points of view on their approach and the theoretical framework behind their choices. An appreciation of the strengths and weaknesses of brain imaging technology applied to pain research in humans provides the tools required to understand current cutting edge literature on the topic. Chapters covering placebo effects in analgesia and the psychology of pain give a thorough overview of cognitive, psychological and social influences on pain perception. Sections exploring pain in the lifecycle and in relation to nervous system disorders take particular relevance from a clinical point of view. Furthermore, an intellectually stimulating chapter analysing the co-morbidity of pain and depression provides a philosophical angle rarely presented in related handbooks. The references to external research databases and relevant websites aim to prompt readers to become critical and independent thinkers, and motivate them to carry out further reading on these topics.

Introduction to Pain and its relation to Nervous System Disorders is essential reading for advanced undergraduate and postgraduate students in neuroscience, medical and biomedical sciences, as well as for clinical and medical healthcare professionals involved in pain management.

List of contributors ix

Foreword xiii

Acknowledgements xv

Notes on authors xvii

Introduction 1

Section I: Neurobiology of pain: Recent advances 11

1 Anatomy of pain pathways 13
Andrew J. Todd

2 Spinal plasticity of the nociceptive system: The role of central sensitization in chronic pain states 35
Alban Latremolière

3 Symptoms and pathology in neuropathic pain 89
Matthew Thakur and Stephen B. McMahon

4 Recent advances in neuroimmune interactions in neuropathic pain: The role of microglia 123
Elizabeth A. Old, Louise S. C. Nicol and Marzia Malcangio

5 Genetics and epigenetics of pain 149
Franziska Denk and Stephen B. McMahon

6 The cannabinoid system and its role in nociception 169
Massimiliano Beltramo

7 EphB receptors and persistent pain 201
Isabella Gavazzi

Section II: Pain in the brain 225

8 Brain imaging in experimental pain 227
Massieh Moayedi and Tim V. Salomons

9 Placebo effects in pain 249
Luana Colloca, Adam P. Horin and Damien Finniss

10 Psychology and pain 267
Lance M. McCracken

Section III: Pain in the lifecycle and in nervous system disorders 281

11 Pain in neonates and infants 283
Fiona Moultrie, Sezgi Goksan, Ravi Poorun and Rebeccah Slater

12 How do people with autism spectrum disorders (ASD) experience pain? 295
Cecile Rattaz, Amandine Dubois and Amaria Baghdadli

13 Pain and depression: The janus factor of human suffering 317
Angela Iannitelli and Paola Tirassa

14 Pain in multiple sclerosis: From classification to treatment 345
Claudio Solaro and Michele Messmer

15 Pain perception in dementia 361
Miriam Kunz and Stefan Lautenbacher

16 The role of cognitive impairment in the placebo and nocebo effects 373
Martina Amanzio

17 An overview of pain in parkinson’s disease 387
Panagiotis Zis, Elisaveta Sokolov and Kallol Ray Chaudhuri

Appendix: Interviews with chronic pain patients 409

Index 000