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Analgesics: From Chemistry and Pharmacology to Clinical Application

Analgesics: From Chemistry and Pharmacology to Clinical Application

Helmut Buschmann (Editor), Thomas Christoph (Editor), Elmar Friderichs (Editor), Corinna Maul (Editor), Bernd Sundermann (Editor)

ISBN: 978-3-527-60561-3

Dec 2005

613 pages

Select type: Wiley Online Book

Description

Classified by their mode of action, all important classes of analgesics are presented here, including recent developments that have not yet been introduced to the market. Altogether, more than 300 compounds are described. A carefully designed layout presents the most relevant information at a glance, including compound structure, physical properties, synthesis schemes and clinical uses. Trade names for different countries are also given, allowing quick reference to compounds currently on the market.
In addition to proven pain relievers, novel approaches to pain treatment are discussed and drug candidates for future therapies are presented.
With its broad scope and extensive compound listings, this is a premier reference source for pain treatment by pharmacological means. A valuable resource for clinicians, drug developers and pain researchers.
INTRODUCTION
What is Pain?
PAIN THERAPY TODAY
COX Inhibition: From NSAIDS to Selective Inhibitors
Opioids
Introduction
Opioid Peptides
Synthetic Opioids
Opioids with Clinical Relevance
The delta Opioid Receptor
Opioid-like Receptor (ORL1)
Drug Delivery Systems for Opioids
Noradrenaline and Serotonin Reuptake Inhibitors
NEW APPROACHES IN PAIN THERAPY
Gabapentin and Gabapentinoids
Voltage-gated Ion Channels
Sodium Channels
Potassium Channels
Calcium Channels
Glutamate Receptors
Metabotropic Glutamate Receptors
NMDA Receptors
AMPA and Kainate Receptors
Acetylcholine Receptors
Nicotinic Acetylcholine Receptors
Muscarinic Acetylcholine Receptors
Adenosine in Pain Management
P2 Receptors in Pain
Natural and Synthetic Cannabinoids
Vanilloids and the VR1 Receptor
Substance P/NK1 Receptors
CGRP1 Receptor Antagonists in Pain and Migraine
Nitric Oxide
Outlook-The Future of Pain Management
GLOSSARY
INDEX
""The book is highly informative and will be of value to teachers and students as well as to researchers in the area of analgesics and pain management.""
(Journal of Medicinal Chemistry)