Skip to main content

Analogue-based Drug Discovery II

E-Book

$197.99

Analogue-based Drug Discovery II

János Fischer (Editor), C. Robin Ganellin (Editor)

ISBN: 978-3-527-63212-1 August 2010 564 Pages

E-Book
$197.99
Hardcover
$246.50
O-Book
Download Product Flyer

Download Product Flyer

Download Product Flyer is to download PDF in new tab. This is a dummy description. Download Product Flyer is to download PDF in new tab. This is a dummy description. Download Product Flyer is to download PDF in new tab. This is a dummy description. Download Product Flyer is to download PDF in new tab. This is a dummy description.

Description

Born out of a project of the IUPAC's committee on Medicinal Chemistry and Drug Development, this reference addresses past and current strategies for successful drug analog development, extending the previously published volume by nine new analog classes and eight case studies. Like its precursor, this volume also contains a general section discussing universally applicable strategies for analog discovery and development. Spanning a wide range of therapeutic fields and chemical classes, the two volumes together constitute the first systematic approach to drug analog development.
Of interest to virtually every researcher working in drug discovery and pharmaceutical chemistry.
PART I GENERAL ASPECTS
Optimizing Drug Therapy by Analogues
Standalone Drugs
Application of Molecular Modeling in Analogue-Based Drug Discovery
Issues for the Patenting of Analogues

PART II ANALOGUE CLASSES
Dipeptidyl Peptidase IV Inhibitors for the Treatment of Type 2 Diabetes
Phosphodiesterase 5 Inhibitors to Treat Erectile Dysfunction
Rifamycins, Antibacterial Antibiotics and Their New Applications
Monoterpenoid Indole Alkaloids, CNS Anticancer Drugs
Anthracyclines, Optimizing Anticancer Analogues
Paclitaxel and Epothilone Analogues, Anticancer Drugs
Selective Serotonin Reuptake Inhibitors for the Treatment of Depression
Muscarinic Receptor Antagonists in the Treatment of COPD
beta-Adrenoceptor Agonists and Asthma

PART III CASE HISTORIES
Liraglutide, a GLP-1 Analogue to Treat Diabetes
Eplerenone: Selective Aldosterone Antagonist
Clevudine, to Treat Hepatitis B Viral Infection
Rilpivirine, a Non-nucleoside Reverse Transcriptase Inhibitor to Treat HIV-1
Tipranavir, a Non-Peptidic Protease Inhibitor for Multi-drug Resistant HIV
Lapatinib, an Anticancer Kinase Inhibitor
Dasatinib, a Kinase Inhibitor to Treat Chronic Myelogenous Leukemia
Venlafaxine and Desvenlafaxine, Selective Norepinephrine and Serotonin Reuptake Inhibitors to Treat Major Depressive Disorder
"Analogue-Based Drug Discovery II is a companion book to the first volume ... This volume provides an excellent
overview of several biological targets, compound classes, and illustrations of problem solving in medicinal chemistry for chemists in drug discovery who are beginning to establish their careers" (ChemMedChem, 1 January 2012)