Antibacterial Agents: Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications
Section One - Introduction to Micro-organisms and Antibacterial Chemotherapy
- · Micro-organisms - Classification; DNA Replication; Metabolic Processes (Folic Acid Synthesis); Protein Synthesis; Bacterial Cell Wall Synthesis; Bacterial Detection and Identification; Other than its mode of action, what factors determine the antibacterial activity of a drug?; The ‘Post-Antibiotic Age’?
Section Two - Agents Targeting DNA
- Quinolone Antibacterial Agents
- Rifamycin Antibacterial Agents
- & Nitroimidazole Antibacterial Agents
Section Three - Agents Targeting Metabolic Processes
- Sulfonamide Antibacterial Agents
Section Four - Agents Targeting Protein Synthesis
- Aminoglycoside Antibiotics
- Macrolide Antibiotics
- Tetracycline Antibiotics
Section Five - Agents Targeting Cell Wall Synthesis
- β-Lactam Antibiotics
- Glycopeptide Antibiotics
- By categorizing and presenting antibacterial agents by target rather than by chemical class the book supports the thorough comprehension of the mechanism of action of these agents and also how resistance can arise.
- Integrated “lab-to-clinic” approach covers aspects from drug discovery and mechanism of action through to clinical applications.
- Incorporates results from the relevant Cochrane reviews.
- Literature sources are provided for further reading
- Diagrams are presented in full colour