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Antigen Presenting Cells: From Mechanisms to Drug Development

Antigen Presenting Cells: From Mechanisms to Drug Development

Harald Kropshofer (Editor), Anne B. Vogt (Editor)

ISBN: 978-3-527-60698-6

May 2006, Wiley-Blackwell

651 pages

$269.99

Description

This novel, multidisciplinary handbook highlights recent evidence that antigen presenting cells (APCs) are not only key players in the initiation or prevention of an antigen-specific T lymphocyte-mediated adaptive immune response, but also critical regulators and integrators in the interplay between our innate and adaptive immune system.
Structured in a clear way to allow access to a very broad readership, the book is written from the viewpoint of a biochemist, immunologist, and scientist with experience in drug development. It covers all cell types involved in antigen presentation, providing the latest immunological facts with a focus on drug development.
Backed by a glossary explaining all important technical terms, this short but comprehensive reference covers basic introductory aspects right up to details for advanced specialists.
Introduction
Some old and new findings on antigen processing and presentation
Antigen entry routes - where foreign invaders meet antigen presenting cells
Antigen processing in the context of MHC class I molecules
Antigen processing for MHC Class II
Antigen processing and presentation by CD1 family proteins
Naturally processed self-peptides of MHC molecules
Target cell contributions to cytotoxic T cell sensitivity
Stimulation of antigen presenting cells: from classical adjuvants to Toll-like receptor (TLR) ligands
Evolution and diversity of macrophages
Macrophages -
Balancing tolerance and immunity
Polymorphonuclear neutrophils as antigen-presenting cells
Microglial - the professional antigen presenting cells of the CNS?
The contribution of B cells to autoimmune pathogenesis
Dendritic cells (DCs) in immunity and maintenance of tolerance
Thymic dendritic cells
Antigen-presenting cells as drug targets
Glossary
"Structured in a clear way to allow access to a very broad readership ...providing the latest immunological facts ... Backed by a glossary explaining all important technical terms, this short but comprehensive reference covers basic introductory aspects right up to details for advanced specialists."
Clinical Laboratory