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Antimicrobial Peptides

Antimicrobial Peptides

David A. Phoenix, Sarah R. Dennison, Frederick Harris

ISBN: 978-3-527-65287-7

Dec 2012

248 pages

$136.99

Description

In this text, the small team of expert authors presents the field in a comprehensive and accessible manner that is well suited for students and junior researchers.

The result is a highly readable and systematically structured introduction to antimicrobial peptides, their structure, biological function and mode of action. The authors point the way towards a rational design of this potentially highly effective new class of clinical antibiotics on the brink of industrial application. They do this by discussing their design principles, target membranes and structure-activity relationships. The final part of the book describes recent successes in the application of peptides as anticancer agents.
PREFACE

ANTIMICROBIAL PEPTIDES: THEIR HISTORY, EVOLUTION, AND FUNCTIONAL PROMISCUITY
Introduction: The History of Antimicrobial Peptides
AMPs: Evolutionarily Ancient Molecules
AMPs: Multifunctional Molecules
Discussion

CATIONIC ANTIMICROBIAL PEPTIDES
Introduction
CAMPs and Their Antimicrobial Action
CAMPs That Adopt an alpha-Helical Structure
CAMPs That Adopt a ß-Sheet Structure
CAMPs That Adopt Extended Structures Rich in Specific Residues
Discussion

ANIONIC ANTIMICROBIAL PEPTIDES
Introduction
AAMPs in the Respiratory Tract
AAMPs in the Brain
AAMPs in the Epidermis
AAMPs in the Epididymis
AAMPs in Blood Components
AAMPs in the Gastrointestinal Tract and Food Proteins
AAMPs and Their Structure -
Function Relationships
Discussion

GRAPHICAL TECHNIQUES TO VISUALIZE THE AMPHIPHILIC STRUCTURES OF ANTIMICROBIAL PEPTIDES
Introduction
Amphiphilic Structures Adopted by AMPs
Qualitative Methods for Identifying Amphiphilic Structure
Quantitative Techniques for Analyzing Amphiphilic Structure
Discussion

MODELS FOR THE MEMBRANE INTERACTIONS OF ANTIMICROBIAL PEPTIDES
Introduction
CM-Associated Factors That Affect the Antimicrobial Action of a-CAMPs
Mechanisms Used by CAMPs for Microbial Membrane Interaction
Established Models for the Membrane Interactions of a-AMPs
Recent Novel Models for the Membrane Interactions of a-AMPs
Tilted Peptide Mechanism
Amyloidogenic Mechanisms
Discussion

SELECTIVITY AND TOXICITY OF ONCOLYTIC ANTIMICROBIAL PEPTIDES
Introduction
Peptide-Based Factors That Contribute to the Anticancer Action of Anticancer Peptides
Membrane-Based Factors That Contribute to the Anticancer Action of ACPs
Discussion

INDEX