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Antiplatelet Therapy In Ischemic Heart Disease

Antiplatelet Therapy In Ischemic Heart Disease

Stephen D. Wiviott

ISBN: 978-1-444-30334-6 January 2009 Wiley-Blackwell 312 Pages




This book in the new American Heart Association Clinical Series, explores and explains state-of-the-art use of antiplatelet agents and draws on the expertise of global leaders in antiplatelet therapy. Skillfully organized for fast reference, the book is divided into five parts:

  • Concepts in Platelet Physiology, Function, and Measurement
  • Pharmacology of Oral Antiplatelet Agents
  • Pharmacology of Intravenous Antiplatelet Agents
  • Clinical Use of Antiplatelet Agents in Cardiovascular Disease
  • Special Circumstances.

Each chapter in the clinical section contains an overview of guidelines, plus specifics on medical and interventional uses.

Clinical cardiologists, platelet biologists, and a wide range of practicing and prospective clinicians in allied fields will find this text an exceptional source of current information.

Part I Concepts in Platelet Physiology, Function and Measurement.

1 Platelet physiology and the role of the platelet in ischemic heart disease.

Robert F. Storey .

2 Laboratory assessment of platelet function and the effects of antiplatelet agents.

Alan D. Michelson, A.L. Frelinger .

Part II Pharmacology of Oral Antiplatelet Agents.

3 Cyclooxygenase inhibitors.

Nina Chetty Raju, John W. Eikelboom .

4 Aspirin response variability and resistance.

Wai-Hong Chen, Daniel I. Simon .

5 P2Y12 inhibitors: Thienopyridines and direct oral inhibitors.

Jean-Philippe Collet, Boris Aleil, Christian Gachet, Gilles Montalescot .

6 Thienopyridine response variability and resistance.

Udaya S. Tantry, Thomas A. Suarez, Paul A. Gurbel .

Part III Pharmacology of Intravenous Antiplatelet Agents.

7 Pharmacology of intravenous glycoprotein IIb/IIIa antagonists.

James C. Blankenship, Peter B. Berger .

8 Intravenous P2Y12 inhibitors.

Steven P. Dunn, Steven R. Steinhubl .

9 Antiplatelet effects of thrombin inhibitors and fibrinolytic agents.

Nicolai Mejevoi, Anjum Tanwir, Marc Cohen .

Part IV Clinical Use of Antiplatelet Agents in Cardiovascular Disease.

10 Antiplatelet therapy in acute coronary syndrome with ST elevation.

Christian W. Hamm .

11 Antiplatelet therapy in ST-elevation myocardial infarction.

Michelle O'Donoghue, Marc S. Sabatine .

12 Antiplatelet therapy in chronic artery disease.

Kamran I. Muhammed, Deepak L. Bhatt .

13 Antiplatelet therapy in peripheral arterial disease.

Esther S. Kim, Heather L. Gornik .

14 Clinical use of antiplatelet agents in cardiovascular disease: cerebrovascular diseases.

Larry B. Goldstein .

Part V Special Circumstances.

15 Antiplatelet therapy and coronary bypass surgery: risks and benefits.

A. Burdess, N.L. Cruden, K.A. Fox .

16 Management of antiplatelet therapy for non-cardiac surgery.

Nisheeth Goel, John F. Canales, James J. Ferguson .

17 Antiplatelet therapy and coronary stents.

Alanna Coolong, Laura Mauri

“This thorough book addresses the topic in a concise manner. It can be used as a quick reference by busy practitioners or as a teaching guide for students.” (Doody's Reviews, June 2009)
Comprehensive and in-depth reference of antiplatelet theory

  • Draws from expertise of leaders in antiplatelet therapy
  • Easy-to-use layout enables rapid browsing
  • Edited by a member of the prestigious TIMI study group with long-standing experience in the field