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Arsenic: Exposure Sources, Health Risks, and Mechanisms of Toxicity

Arsenic: Exposure Sources, Health Risks, and Mechanisms of Toxicity

J. Christopher States

ISBN: 978-1-118-87678-7

Oct 2015

672 pages



This book illustrates the chemistry, toxicology, and health effects of arsenic using novel modeling techniques, case studies, experimental data, and future perspectives.

•    Covers exposure sources, health risks, and mechanisms of one of the most toxic minerals in the world
•    Helps readers understand potential health effects of arsenic, using population studies, mammalian and invertebrate models, and pharmacokinetic and toxicokinetic models
•    Discusses outcomes, epidemiology, real-life examples, and modes of action for arsenic-induced diseases, like lung cancer, diabetes, cardiovascular and pulmonary diseases, and immunotoxicity
•    Acts as a reference for toxicologists, environmental chemists, and risk assessors and includes up-to-date, novel modeling techniques for scientists
•    Includes future perspectives on special topics, like extrapolation from experimental models to human exposures, biomarkers for phenotypic anchoring, and pathology of chronic exposure

Section I: Fundamentals of Arsenic Exposure and Metabolism

Chapter 1: History of Arsenic as a Poison and Medicinal 4

Chapter 2: Geogenic and Anthropogenic Arsenic Hazard in Groundwaters and Soils – Distribution, Nature, Origin & Human Exposure Routes 34

Chapter 3: Remediation of Arsenic in Drinking Water 115

Chapter 4: The Chemistry and Metabolism of Arsenic 149

Section II: Epidemiology and Disease Manifestations of Arsenic Exposure

Chapter 5: Human Population Studies and Nutritional Intervention 203

Chapter 6: Skin manifestations of chronic arsenicosis 230

Chapter 7: Lung cancer and other pulmonary diseases 247

Chapter 8: Bladder Cancer and Arsenic 300

Chapter 9: Neurological Effects of Arsenic Exposure 342

Chapter 10: Diabetes Mellitus 387

Chapter 11: Hepatotoxicity 428

Chapter 12: Genetic Epidemiology of Susceptibility to Arsenic-induced Diseases 457

Section III. Mechanisms of Toxicity

Chapter 13: Arsenic Interaction with Zinc Finger Motifs 501

Chapter 14: Role In Chemotherapy 545

Chapter 15: Genotoxicity 607

Chapter 16: Arsenic and Signal Transduction 650

Chapter 17: Stem Cell Targeting and Alteration by Arsenic 704

Chapter 18: Epigenetics and Arsenic Toxicity 748

Section IV: Models for Arsenic Toxicology, Risk Assessment

Chapter 19: Cancer Induced by Exposure to Arsenicals in Animals 779

Chapter 20: Arsenic induced cardiovascular disease 804

Chapter 21: Invertebrate Models in Arsenic Research: Past, Present & Future 835

Chapter 22: Toxicokinetics and Pharmacokinetic Modelling of Arsenic 884

Chapter 23: Considerations for a Biologically Based Risk Assessment for Arsenic 909

Chapter 24: Translating experimental data to human populations 955