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Bacterial and Eukaryotic Porins: Structure, Function, Mechanism

Bacterial and Eukaryotic Porins: Structure, Function, Mechanism

Roland Benz (Editor)

ISBN: 978-3-527-60422-7

Mar 2006

382 pages

Select type: E-Book

$172.99

Description

This first book dedicated to the topic relates the known physiological functions of porins to their molecular structure and mechanism, as documented by various in vitro and in vivo methods, including the generation of null mutants in mice.
For the first time, it brings together biophysical evidence with studies performed in a cellular context, presenting a unified picture of the fundamental importance of porins for cellular function.
With 16 contributions by an interdisciplinary team of leading porin researchers, this reference is essential reading for every molecular or structural biologist with an interest in this essential protein family.
Regulation of Porin Gene Expression by the Two-Component Regulatory System EnvZ/OmpR
The Structures of General Porins
Role of bacterial porins in antibiotic susceptibility of gram-negative bacteria
Porins of the Outer Membrane of Pseudomonas aeruginosa
Regulation of Bacterial Porin Function
Reconstitution of General Diffusion Pores from Bacterial Outer Membranes
OmpA/OprF: Slow Porins or Channels Produced by Alternative Folding of Outer Membrane Proteins
Drug Efflux and Protein Export through Channel-tunnels
Structure-Function Relationships in Sugar-Specific Porins
Role of the Carbohydrate-Specific Maltoporin in Substrate Uptake
Functional Reconstitution of Specific Porins
Energy-Coupled Outer Membrane Iron Transporters
Structural and Functional Aspects of the Vitamin B12 Receptor BtuB
Structure and Function of Mitochondrial Porins
Mitochondrial Porins in Mammals: Insights Into Functional Roles From Mutant Mice and Cells
Gene Family Expression and Multitopological Localization of Eukaryotic Porin/VDAC
Function of the Outer Mitochondrial Membrane Pore (VDAC) in Intracellular Signalling
""…a scholarly research monograph on the biophysical aspects of porins…recommended for molecular and structural biologists working with porin proteins and academic libraries…"" (E-STREAMS, May 2005)

“This excellent book should be present in all laboratories…the information is extremely up-to-date and is supported by high-quality and highly original graphics.” (International Microbiology, Vol.7, 2004)