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Bioactive Heterocyclic Compound Classes: Pharmaceuticals and Agrochemicals, 2 Volume Set

Bioactive Heterocyclic Compound Classes: Pharmaceuticals and Agrochemicals, 2 Volume Set

Clemens Lamberth (Editor) , Jürgen Dinges (Editor)

ISBN: 978-3-527-32993-9

Oct 2012

670 pages

Select type: Hardcover

Out of stock

$431.00

Description

Filling a gap in the market, this two-volume set is the first to present important pharmaceuticals as well as agrochemical pesticides in one handy work.
Each of the around 40 chapters covers in a concise manner one class of heterocycles, clearly structured as follows:
* Structural formulas of most important examples (market products)
* Short background of history or discovery
* Typical syntheses of important examples
* Mode of action
* Characteristic biological activity
* Structure-activity relationship
* Additional chemistry information (e.g. further transformations, alternative syntheses, metabolic pathways, etc.)
* References.
A valuable one-stop reference source for researchers in academia and industry as well as for graduate students with career aspirations in the field of pharmaceutical and agrochemical chemistry.

AGROCHEMICALS

THE SIGNIFICANCE OF HETEROCYCLES FOR PHARMACEUTICALS AND AGROCHEMICALS
Introduction
Heterocycles as Framework of Biologically Active Compounds
Fine-Tuning the Physicochemical Properties with Heterocycles
Heterocycles as Prodrugs
Heterocycles as Peptidomimetics
Heterocycles as Isosteric Replacement of Functional Groups
Heterocycles as Isosteric Replacement of Alicyclic Rings
Heterocycles as Isosteric Replacement of other Heterocyclic Rings

PART I: Herbicides

TRIAZINE HERBICIDES
Introduction
History
Synthesis
Mode of Action
Biological Activity
Structure -
Activity Relationships

PYRIMIDINYL AND TRIAZINYLSULFONYLUREA HERBICIDES
Introduction
History
Synthesis
Mode of Action
Biological Activity
Structure -
Activity Relationship

ACETOHYDROXYACID SYNTHASE INHIBITING TRIAZOLOPYRIMIDINE HERBICIDES
Introduction
History
Synthesis
Mode of Action
Biological Activity
Structure -
Activity Relationship

HPPD-INHIBITING BENZOYLPYRAZOLE HERBICIDES
Introduction
History
Synthesis
Mode of Action
Biological Activity
Structure -
Activity Relationship

PYRIDYLOXYPHENOXYPROPIONATE HERBICIDES: INHIBITORS OF ACETYL-COACARBOXYLASE
Introduction
History
Synthesis
Mode of Action
Biological Activity
Structure -
Activity Relationships

IMIDAZOLINONE HERBICIDES
Introduction
History
Synthesis
Mode of Action
Biological Activity
Structure -
Activity Relationship

PROTOPORPHYRINOGEN-IX-OXIDASE-INHIBITING URACIL HERBICIDES
Introduction
History
Synthesis
Mode of Action
Biological Activity
Structure -
Activity Relationship

PART II: Fungicides

BENZIMIDAZOLE FUNGICIDES
Introduction
History
Synthesis
Mode of Action
Biological Activity
Structure -
Activity Relationship

MORPHOLINE FUNGICIDES FOR THE TREATMENT OF POWDERY MILDEW
Introduction
History
Synthesis
Mode of Action
Biological Activity
Structure -
Activity Relationship

STEROL BIOSYNTHESIS INHIBITING TRIAZOLE FUNGICIDES
Introduction
History
Synthesis
Mode of Action
Biological Activity
Structure -
Activity Relationship

METHIONINE BIOSYNTHESIS-INHIBITING ANILINOPYRIMIDINE FUNGICIDES
Introduction
History
Synthesis
Mode of Action
Biological Activity
Structure -
Activity Relationship

PHENYLPYRROLE FUNGICIDES
Introduction
History
Synthesis
Mode of Action
Biological Activity
Structure -
Activity Relationship

BROAD-SPECTRUM FUNGICIDALLY ACTIVE PYRIMIDINYLDIOXY STROBILURINS INHIBITING THE RESPIRATORY CHAIN
Introduction
History
Synthesis
Mode of Action
Biological Activity
Structure -
Activity Relationship

PYRAZOLE CARBOXAMIDE FUNGICIDES INHIBITING SUCCINATE DEHYDROGENASE
Introduction
History
Synthesis
Mode of Action
Biological Activity
Structure -
Activity Relationships

PART III: Insecticides

AVERMECTIN INSECTICIDES AND ACARICIDES
Introduction
History
Synthesis
Mode of Action
Biological Activity
Structure -
Activity Relationship

PYRIDINE AND THIAZOLE-CONTAINING INSECTICIDES AS POTENT AGONISTS ON INSECT NICOTINIC ACETYLCHOLINE RECEPTORS
Introduction
History
Synthesis
Mode of Action
Biological Activity
Structure -
Activity Relationship

PYRAZOLE AND PYRIMIDINE ACARICIDES AND INSECTICIDES ACTING AS INHIBITORS OF MITOCHONDRIAL ELECTRON TRANSPORT AT COMPLEX I
Introduction
History
Synthesis
Mode of Action
Biological Activity
Structure -
Activity Relationship

PHENYLPYRAZOLE-CONTAINING FIPROLE INSECTICIDES
Introduction
History
Synthesis
Mode of Action
Biological Activity
Structure -
Activity Relationship

PYRAZOLYLPYRIDINE ACTIVATORS OF THE INSECT RYANODINE RECEPTOR
Introduction
History
Synthesis
Mode of Action
Biological Activity
Structure -
Activity Relationships

TETRONIC ACID INSECTICIDES AND ACARICIDES INHIBITING ACETYL-COACARBOXYLASE
Introduction
History
Synthesis
Mode of Action
Biological Activity
Structure -
Activity Relationship

PHARMACEUTICALS

THE SIGNIFICANCE OF HETEROCYCLES FOR PHARMACEUTICALS AND AGROCHEMICALS
Introduction
Heterocycles as Framework of Biologically Active Compounds
Fine-Tuning the Physicochemical Properties with Heterocycles
Heterocycles as Prodrugs
Heterocycles as Peptidomimetics
Heterocycles as Isosteric Replacement of Functional Groups
Heterocycles as Isosteric Replacement of Alicyclic Rings
Heterocycles as Isosteric Replacement of other Heterocyclic Rings

PART I: Neurological Disorders

TROPANE-BASED ALKALOIDS AS MUSCARINIC ANTAGONISTS FOR THE TREATMENT OF ASTHMA, OBSTRUCTIVE PULMONARY DISEASE, AND MOTION SICKNESS
Introduction
History
Synthesis
Mode of Action
Structure -
Activity Relationships

MORPHINONE-BASED OPIOID RECEPTOR AGONIST ANALGESICS
Introduction
History
Synthesis
Mode of Action
Structure -
Activity Relationship

BARBITURIC ACID-BASED GABA(A) RECEPTOR MODULATORS FOR THE TREATMENT OF SLEEP DISORDER AND EPILEPSY AND AS ANESTHETICS
Introduction
History
Synthesis
Mode of Action
Structure -
Activity Relationship

PHENOTHIAZINE-BASED DOPAMINE D2 ANTAGONISTS FOR THE TREATMENT OF SCHIZOPHRENIA
Introduction
History
Synthesis
Mode of Action
Structure -
Activity Relationships

ARYLPIPERAZINE-BASED 5-HT1A RECEPTOR PARTIAL AGONISTS AND 5-HT2A ANTAGONISTS FOR THE TREATMENT OF AUTISM, DEPRESSION, ANXIETY, PSYCHOSIS, AND SCHIZOPHRENIA
Introduction
History
Synthesis
Mode of Action
Structure -
Activity Relationship

ARYLPIPERIDINE-BASED DOPAMINE D2 ANTAGONISTS/5-HT2A ANTAGONISTS FOR THE TREATMENT OF AUTISM, DEPRESSION, SCHIZOPHRENIA, AND BIPOLAR DISORDER
Introduction
History
Synthesis
Mode of Action
Structure -
Activity Relationship

DIBENZAZEPINE-BASED SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF NEUROPATHIC PAIN
Introduction
History
Synthesis
Mode of Action
Structure -
Activity Relationships

PART II: Cardiovascular Diseases

DIHYDROPYRIDINE-BASED CALCIUM CHANNEL BLOCKERS FOR THE TREATMENT OF ANGINA PECTORIS AND HYPERTENSION
Introduction
History
Synthesis
Mode of Action
Structure -
Activity Relationship

TETRAZOLE-BASED ANGIOTENSIN II TYPE 1 (AT1) ANTAGONISTS FOR THE TREATMENT OF HEART FAILURE AND CONGESTIVE HYPERTENSION
Introduction
History
Synthesis
Mode of Action
Structure -
Activity Relationship

THIAZIDE-BASED DIURETICS FOR THE TREATMENT OF HYPERTENSION AND GENITOURINARY DISORDERS
Introduction
History
Synthesis
Mode of Action
Structure -
Activity Relationship

TETRAHYDROPYRANONE-BASED HMG-COA REDUCTASE INHIBITORS FOR THE TREATMENT OF ARTERIAL HYPERCHOLESTEROLEMIA
Introduction
History
Synthesis
Mode of Action
Structure -
Activity Relationship

PART III: Infectious Diseases

ADENINE-BASED REVERSE TRANSCRIPTASE INHIBITORS AS ANTI-HIV AGENTS
Introduction
History
Synthesis
Mode of Action
Structure -
Activity Relationship

GUANINE-BASED NUCLEOSIDE ANALOGS AS ANTIVIRAL AGENTS
Introduction
History
Synthesis
Mode of Action
Structure -
Activity Relationship

PENICILLIN AND CEPHALOSPORIN ANTIBIOTICS
Introduction
History
Synthesis
Mode of Action
Structure -
Activity Relationships

PART IV: Oncology

PYRIMIDINE-BASED KINASE INHIBITORS IN CANCER CHEMOTHERAPY
Introduction
History
Synthesis
Mode of Action
Structure -
Activity Relationship

BENZYL TRIAZOLE-BASED AROMATASE INHIBITORS FOR THE TREATMENT OF BREAST CANCER
Introduction
History
Synthesis
Mode of Action
Structure -
Activity Relationship

PART V: Inflammation and Gastrointestinal Diseases

ACETONIDE-BASED GLUCOCORTICOIDS FOR THE TREATMENT OF ASTHMA, SKIN INFLAMMATION, AND DISEASES OF THE EYE
Introduction
History
Synthesis
Mode of Action
Structure -
Activity Relationship

BENZIMIDAZOLE-BASED H+/K+-ATPASE INHIBITORS FOR THE TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE
Introduction
History
Synthesis
Mode of Action
Structure -
Activity Relationships

PART VI: Metabolic Diseases

THIAZOLIDINEDIONE-BASED INSULIN SENSITIZERS:PPAR-G AGONISTS FOR THE TREATMENT OF TYPE 2 DIABETES
Introduction
History
Synthesis
Mode of Action
Structure -
Activity Relationship