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Biochemistry, 4th Edition

Biochemistry, 4th Edition

Donald Voet, Judith G. Voet

ISBN: 978-0-470-57095-1

Dec 2010

1520 pages

In Stock

$300.95

Description

The “Gold Standard” in Biochemistry text books. Biochemistry 4e, is a modern classic that has been thoroughly revised. Don and Judy Voet explain biochemical concepts while offering a unified presentation of life and its variation through evolution. It incorporates both classical and current research to illustrate the historical source of much of our biochemical knowledge.

Related Resources

Guide to Media Resources xvi

PART I INTRODUCTION AND BACKGROUND 1

1 Life 3

2 Aqueous Solutions 40

3 Thermodynamic Principles: A Review 52

PART II BIOMOLECULES 65

4 Amino Acids 67

5 Nucleic Acids, Gene Expression, and Recombinant DNA Technology 82

6 Techniques of Protein and Nucleic Acid Purifications 129

7 Covalent Structures of Proteins and Nucleic Acids 163

8 Three-Dimensional Structures of Proteins 221

9 Protein Folding, Dynamics, and Structural Evolution 278

10 Hemoglobin: Protein Function in Microcosm 323

11 Sugars and Polysaccharides 359

12 Lipids and Membranes 386

PART III MECHANISMS OF ENZYME ACTION 467

13 Introduction to Enzymes 469

14 Rates of Enzymatic Reactions 482

15 Enzymatic Catalysis 506

PART IV METABOLISM 557

16 Introduction to Metabolism 559

17 Glycolysis 593

18 Glycogen Metabolism 638

19 Signal Transduction 671

20 Transport through Membranes 744

21 Citric Acid Cycle 789

22 Electron Transport and Oxidative Phosphorylation 823

23 Other Pathways of Carbohydrate Metabolism 871

24 Photosynthesis 901

25 Lipid Metabolism 940

26 Amino Acid Metabolism 1019

27 Energy Metabolism: Integration and Organ Specialization 1088

28 Nucleotide Metabolism 1107

PART V EXPRESSION AND TRANSMISSION OF GENETIC INFORMATION 1143

29 Nucleic Acid Structures 1145

30 DNA Replication, Repair, and Recombination 1173

31 Transcription 1260

32 Translation 1338

33 Viruses: Paradigms for Cellular Function W-1

34 Eukaryotic Gene Expression W-53

35 Molecular Physiology W-165

(Chapters 33–35 are available on our website, www.wiley.com/college/voet)

xii

  • Many new and updated protein and nucleic acid structures
  • Next generation DNA sequencing technologies
  • New methods of protein structure prediction and design
  • Discussion of glycomics
  • How transmembrane proteins are inserted into membranes
  • Updated discussions on vesicle formation and fusion
  • Mechanism of nitric oxide synthase
  • Structural characterization of G protein-coupled receptors
  • Structures of (Na+-K+)-, Ca2+-, and (H+-K+)-ATPases
  • ABC Transporters
  • Voltage-gated ion channels
  • Structures of all components of the electron transport system
  • Structures of photosystems I and II
  • Structures of fatty acid synthases
  • Structure of topoisomerase II
  • Mechanism of helicases
  • Updated mechanisms of DNA replication
  • DNA replication initiation
  • Replication of mitochondrial DNA
  • Mechanism of recombination
  • Structure and mechanism of RecBCD
  • Structure and mechanism of RNA polymerase II
  • Structure and mechanism of Rho factor
  • Structure of a group I intron
  • Functions of RNAi
  • Mechanism of ribosomal polypeptide synthesis
  • Mechanism of DNA loading in phage heads
  • Structure of chromatin
  • As in past editions, the chemical basis of modern Biochemistry is presented in a thorough and uncompromising fashion. Don and Judy Voet are scholars and teachers who have dedicated their careers to their students and this text.
  • A splendid art program of over 3000 figures presents both classical and contemporary concepts, experiments, and techniques.
  • A lucid and elegant writing style captures the historical foundations of contemporary Biochemistry focusing on the scientific process rather than presenting Biochemistry as a body of static facts isolated from the flesh-and-blood work of experimentalists.
  • Themes throughout the text integrate a vast amount of material. The unity of evolutionary processes, the interdependence of elaborate biological control systems and cascades, and the important biomedical consequences of understanding life at the molecular level are themes woven into the text to give students an intellectually satisfying journey, not just a dry presentation of topics and techniques.