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Biochemistry of Signal Transduction and Regulation, 2nd Edition

Biochemistry of Signal Transduction and Regulation, 2nd Edition

Gerhard Krauss, Bonnie L. Cooper (Translator), Nancy Schönbrunner (Translator)

ISBN: 978-3-527-60005-2

Dec 2001

528 pages

Select type: O-Book


Now the updated second edition of this bestselling title is available as softcover!

Intracellular signal transduction, regulation of cellular activities, tumor formation, apoptosis - how do they work? These questions have become a central topic in Biology and Biological Chemistry. The importance of this field is mirrored in the 1999 Nobel prize for Physiology that went to G. Blobel for his findings in protein transport regulation.

Over the last decade there has been great progress in the understanding of the molecular basis of signal transduction, and many facts are now basic knowledge for every medicinal chemist, biochemist, and biologist. Since an integral description of cellular regulation and signal transduction is scarcely covered in textbooks, this book fills a real gap. Starting from the principles of gene regulation and regulation of enzyme activity, the topics of this book cover function, structure, and integral construction of signalling pathways plus a detailed description of the various types of carriers such as second messengers, protein kinases, and transmembrane receptors. Central cellular processes like cell cycle regulation, oncogenesis and apoptosis are discussed in light of the properties of the signalling molecules involved. With didactic skill and clarity the author relates the observed biological phenomena to the underlying biochemical processes.
This book is actually two books: Regulation and Signal Transduction.
Regulation of Gene Expression
Regulation of Enzyme Activities, 3. Function and Structure of Signalling Pathways, 4. Signal Transduction through Nuclear Receptors, 5. G-Protein-Coupled Signal Transduction Pathways
Intracellular Signalling Agents: 'Second Messenger'
Ser/Thr-Specific Protein Kinases and Protein Phosphatases
Signal Transduction through Transmembrane Receptors with Tyrosine-Specific Protein Kinase Activity
Signal Transduction through Ras-Proteins
Intracellular Signal Transduction: Protein Kinase Cascade of MAP-Kinase Pathways
Membrane Receptors with Associated Tyrosine-Kinase Activity
Transmembrane Receptors with Intrinsic Ser/Thr-Kinase Activity and Signal Transduction in the 'Two-Component Pathway'
Integral Construction, Networks, and Specifity of Signalling Pathways
Regulation of the Cell Cycle
Malfunction of Signalling Pathways and Tumor Formation: Oncogenes and Tumor Suppressants
Ion Channels and Signal Transduction

""...Die klare und didaktisch gute Präsentation macht dieses Lehrbuch sehr nützlich für Studenten und Forscher, die neu auf dem Gebiet der Zellregulation sind."" M.R. Popoff, Biochemie