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Biochemistry of Signal Transduction and Regulation, 2nd Edition

Biochemistry of Signal Transduction and Regulation, 2nd Edition

Gerhard Krauss, Bonnie L. Cooper (Translator), Nancy Schönbrunner (Translator)

ISBN: 978-3-527-60005-2

Dec 2001

528 pages

Select type: O-Book

Description

Now the updated second edition of this bestselling title is available as softcover!

Intracellular signal transduction, regulation of cellular activities, tumor formation, apoptosis - how do they work? These questions have become a central topic in Biology and Biological Chemistry. The importance of this field is mirrored in the 1999 Nobel prize for Physiology that went to G. Blobel for his findings in protein transport regulation.

Over the last decade there has been great progress in the understanding of the molecular basis of signal transduction, and many facts are now basic knowledge for every medicinal chemist, biochemist, and biologist. Since an integral description of cellular regulation and signal transduction is scarcely covered in textbooks, this book fills a real gap. Starting from the principles of gene regulation and regulation of enzyme activity, the topics of this book cover function, structure, and integral construction of signalling pathways plus a detailed description of the various types of carriers such as second messengers, protein kinases, and transmembrane receptors. Central cellular processes like cell cycle regulation, oncogenesis and apoptosis are discussed in light of the properties of the signalling molecules involved. With didactic skill and clarity the author relates the observed biological phenomena to the underlying biochemical processes.
This book is actually two books: Regulation and Signal Transduction.
Chapter 1: The Regulation of Gene Expression.

Chapter 2: The Regulation of Enzyme Activity.

Chapter 3: Function and Structure of Signaling Pathways.

Chapter 4: Signaling by Nuclear Receptors.

Chapter 5: G-protein Coupled Signal Transmission Pathways.

Chapter 6: Intracellular Messenger Substances: "Second Messengers".

Chapter 7: Ser/Thr-specific Protein Kinases and Protein Phosphatases.

Chapter 8: Signal Transmission via Transmembrane Receptors with Tyrosine-specific Protein Kinase Activity.

Chapter 9: Signal Transmission via Ras Proteins.

Chapter 10: Intracellular Signal Transduction: The Protein Cascades of the MAP Kinase Pathways.

Chapter 11: Membrane Receptors with Associated Tyrosine Kinase Activity.

Chapter 12: Other Receptor Classes.

Chapter 13: Regulation of the Cell Cycle.

Chapter 14: Malfunction of Signaling Pathways and Tumorigenesis: Oncogenes and Tumor Suppressor Genes.

Chapter 15: Apoptosis.

Chapter 16: Ion Channels and Signal Transduction.

Subject Index.

"The clear and didactic presentation makes it a textbook very useful for students and researchers not familiar with all aspects of cell regulation." (Biochemie, No. 83, 2001)

"...very comprehensive...useful for teachers, researchers and students..." (Biochemie, Vol.84, No.4, 2002)

"...describes the structural and biochemical properties of signaling molecules and their regulation..." (SciTech Book News, Vol. 26, No. 2, June 2002)

"...should provide a useful guide to undergraduate students..."(Applied Organometallic Chemistry, November 2002)