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Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins, 2nd Edition

Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins, 2nd Edition

Andreas D. Baxevanis, B. F. Francis Ouellette

ISBN: 978-0-471-46101-2

Mar 2004

504 pages

Select type: E-Book



"In this book, Andy Baxevanis and Francis Ouellette . . . have undertaken the difficult task of organizing the knowledge in this field in a logical progression and presenting it in a digestible form. And they have done an excellent job. This fine text will make a major impact on biological research and, in turn, on progress in biomedicine. We are all in their debt."
—Eric Lander from the Foreword

Reviews from the First Edition

"...provides a broad overview of the basic tools for sequence analysis ... For biologists approaching this subject for the first time, it will be a very useful handbook to keep on the shelf after the first reading, close to the computer."
Nature Structural Biology

"...should be in the personal library of any biologist who uses the Internet for the analysis of DNA and protein sequence data."

"...a wonderful primer designed to navigate the novice through the intricacies of in scripto analysis ... The accomplished gene searcher will also find this book a useful addition to their library ... an excellent reference to the principles of bioinformatics."
Trends in Biochemical Sciences

This new edition of the highly successful Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins provides a sound foundation of basic concepts, with practical discussions and comparisons of both computational tools and databases relevant to biological research.

Equipping biologists with the modern tools necessary to solve practical problems in sequence data analysis, the Second Edition covers the broad spectrum of topics in bioinformatics, ranging from Internet concepts to predictive algorithms used on sequence, structure, and expression data. With chapters written by experts in the field, this up-to-date reference thoroughly covers vital concepts and is appropriate for both the novice and the experienced practitioner. Written in clear, simple language, the book is accessible to users without an advanced mathematical or computer science background. This new edition includes:

  • All new end-of-chapter Web resources, bibliographies, and problem sets
  • Accompanying Web site containing the answers to the problems, as well as links to relevant Web resources
  • New coverage of comparative genomics, large-scale genome analysis, sequence assembly, and expressed sequence tags
  • A glossary of commonly used terms in bioinformatics and genomics

Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins, Second Edition is essential reading for researchers, instructors, and students of all levels in molecular biology and bioinformatics, as well as for investigators involved in genomics, positional cloning, clinical research, and computational biology.

Bioinformatics and the Internet (A. Baxevanis & B. Ouellette).

The NCBI Data Model (J. Ostell, et al.).

The GenBank Sequence Database (I. Karsch-Mizrachi & B. Ouellette).

Submitting DNA Sequences to the Databases (J. Kans & B. Ouellette).

Structure Databases (C. Hogue).

Genomic Mapping and Mapping Databases (P. White & T. Matise).

Information Retrieval from Biological Databases (A. Baxevanis).

Sequence Alignment and Database Searching (G. Schuler).

Multiple Sequence Alignment (G. Barton).

Predictive Methods Using DNA Sequences (A. Baxevanis).

Predictive Methods Using Protein Sequences (S. Banerjee-Basu & A. Baxevanis).

Expressed Sequence Tags (ESTs) (T. Wolfsberg & D. Landsman).

Sequence Assembly and Finishing Methods (R. Staden, et al.).

Phylogenetic Analysis (F. Brinkman & D. Leipe).

Comparative Genome Analysis (M. Galperin & E. Koonin).

Large-Scale Genome Analysis (P. Meltzer).

Using Perl to Facilitate Biological Analysis (L. Stein).

"…a well-written and organized guide to mining and analyzing both the mounts of publicly available genetic and protein data as well as one's own data sets…an excellent reference for a wide range of techniques." (American Journal of Physical Anthropology, May 2005)

"...can be used as a classroom text, a tutorial, or a laboratory bench reference...reinforces concepts that have survived...and incorporates new approaches and algorithms for analyzing genes and proteins." (SciTech Book News, Vol. 25, No. 3, September 2001)

"...a great book covering the discipline of bioinformatics.... This high quality book will be helpful to many..." (Lab News, October/November 2001)

"Baxevanis and Ouellette provide a timely update and much new information in this important field. Although each chapter has been revised and updated, the strengths of the first edition remain. The range of topics is comprehensive.... Each topic is presented in an easily accessible style.... An important feature is the frequent discussion of the shortcomings and pitfalls.... A surprising addition, and one that is also surprisingly lucid, practical and even entertaining, is the chapter on Perl programming.... It is most highly recommended for students and for established investigators alike...." (Trends in Genetics)

"[it] is a good practical book and many will benefit from reading it" (Proteomics, May 25, 2001)

"...beneficial to both beginners and experienced readers...this book, written by the top scientists in the field of bioinformatics, is the perfect choice for every molecular biology laboratory" (The Quarterly Review of Biology, March 2002)