Preface to the First Edition.
PART I ANALYZING DNA, RNA, AND PROTEIN SEQUENCES IN DATABASES.
2 Access to Sequence Data and Literature Information.
3 Pairwise Sequence Alignment.
4 Basic Local Alignment Search Tool (BLAST).
5 Advanced Database Searching.
6 Multiple Sequence Alignment.
7 Molecular Phylogeny and Evolution.
PART II GENOMEWIDE ANALYSIS OF RNA AND PROTEIN.
8 Bioinformatic Approaches to Ribonucleic Acid (RNA).
9 Gene Expression: Microarray Data Analysis.
10 Protein Analysis and Proteomics.
11 Protein Structure.
12 Functional Genomics.
PART III GENOME ANALYSIS.
13 Completed Genomes.
14 Completed Genomes: Viruses.
15 Completed Genomes: Bacteria and Archaea.
16 The Eukaryotic Chromosome.
17 Eukaryotic Genomes: Fungi.
18 Eukaryotic Genomes: From Parasites to Primates.
19 Human Genome.
20 Human Disease.
Answers to Self-Test Quizzes.
- Attractive two-color design throughout, with a section of full-color figures
- Lavishly illustrated, featuring over 500 figures and tables with 50 NEW figures and tables in this edition
- Highlights how the tools of bioinformatics can be used to further our understanding of basic processes in cell and molecular biology and genomics
- NEW to the second edition: Several fundamentally important proteins (such as histones, insulin, globins, and albumins) are included to better show how to apply bioinformatics tools to basic biological questions
- Strong focus on the relevance of bioinformatics tools to the understanding of human disease
- Each chapter includes a Problem Set, Pitfalls section, Boxes explaining key techniques and math/stats principles, Summary, Recommended Reading, and a list of freely available Software