Skip to main content

Bioinformatics and Molecular Evolution

Paul G. Higgs, Teresa K. Attwood

ISBN: 978-1-118-69707-8 June 2013 Wiley-Blackwell 448 Pages


In the current era of complete genome sequencing, Bioinformatics and Molecular Evolution provides an up-to-date and comprehensive introduction to bioinformatics in the context of evolutionary biology.

This accessible text:

  • provides a thorough examination of sequence analysis, biological databases, pattern recognition, and applications to genomics, microarrays, and proteomics
  • emphasizes the theoretical and statistical methods used in bioinformatics programs in a way that is accessible to biological science students
  • places bioinformatics in the context of evolutionary biology, including population genetics, molecular evolution, molecular phylogenetics, and their applications
  • features end-of-chapter problems and self-tests to help students synthesize the materials and apply their understanding
  • is accompanied by a dedicated website - - containing downloadable sequences, links to web resources, answers to self-test questions, and all artwork in downloadable format (artwork also available to instructors on CD-ROM).

This important textbook will equip readers with a thorough understanding of the quantitative methods used in the analysis of molecular evolution, and will be essential reading for advanced undergraduates, graduates, and researchers in molecular biology, genetics, genomics, computational biology, and bioinformatics courses.


Chapter Plan.

Chapter 1. Introduction: The Revolution in Biological Information.

Chapter 2. Nucleic Acids, Proteins, and Amino Acids.

Chapter 3. Molecular Evolution and Population Genetics.

Chapter 4. Models of Sequence Evolution.

Chapter 5. Information Resources for Genes and Proteins.

Chapter 6. Sequence Alignment Algorithms.

Chapter 7. Searching Sequence Databases.

Chapter 8. Phylogenetic Methods.

Chapter 9. Patterns in Protein Families.

Chapter 10. Probabilistic Methods and Machine Learning.

Chapter 11. Further Topics in Molecular Evolution and Phylogenetics.

Chapter 12. Genome Evolution.

Chapter 13. DNA Microarrays and the 'omes.

Mathematical Appendix.

List of Web address.



"Finally, it has arrived: The book I can confidently recommend to my students as the best in the field. That this single book has been able to cover so much is testimony to the dedication and quality of the authors." James McInerney, National University of Ireland <!--end-->

"Much of bioinformatics is based on, yet too often ignores, the underlying principles of molecular evolution. This well-written book provides a description of modern bioinformatics methods while providing the biology and evolutionary theory necessary to understand how, why, and when these methods work. This is essential reading for those interested in being either a bioinformatics developer or an informed user." Richard Goldstein, National Institute for Medical Research

"I like the text's balance; it is rigorous without being too formal, and has an accessible and broad coverage of topics from both a computer science and a biology perspective." Mohammad Zaki, Rensselaer Polytechnic Institute

"This book nicely integrates molecular evolution and bioinformatics, two disciplines that go hand in hand, as rightfully claimed by the authors. Many bioinformatics applications are based on principles of molecular evolution, and to study molecular evolution is unthinkable nowadays without having access to the necessary tools and implementations. This is an excellent book for both undergraduate and graduate students, as well as for anyone who wants to solve problems in molecular evolution and needs to know the practicalities." Yves Van de Peer, Ghent University, Belgium

"This book is actually fun! Fun, very educative, well organised, practical and easy to use...I wish this book had been published long ago." The British Toxicology Society Newsletter, November 2005

" excellent and current introduction to classical bioinformatics and an ideal core text for a Master's course in the subject." Comparative and Functional Genomics, November 2005

Test Questions: Chapter 2

This PDF file and the others below require Adobe Reader to view. If your computer is unable to view Adobe PDF files, you can download the free reader from Adobe.

Test Answers: Chapter 2
Test Questions: Chapter 4
Test Answers: Chapter 4
Test Questions: Chapter 7
Test Answers: Chapter 7
Test Questions: Chapter 8
Test Answers: Chapter 8
Test Questions: Chapter 9
Test Answers: Chapter 9
Test Questions: Chapter 13
Test Answers: Chapter 13
Test Questions: Math App
Test Answers: Math App
Downloadable Sequences: CytBDNA.txt
Downloadable Sequences: CytBProt.txt
Downloadable Sequences: Hexokinase.txt
Artwork: Chapter 1

The artwork files for this chapter and the others below are stored in ZIP archives. If your computer is not capable of opening ZIP archives, you can download a free trial of Winzip.

Artwork: Chapter 2
Artwork: Chapter 3
Artwork: Chapter 4
Artwork: Chapter 5
Artwork: Chapter 6
Artwork: Chapter 7
Artwork: Chapter 8
Artwork: Chapter 9
Artwork: Chapter 10
Artwork: Chapter 11
Artwork: Chapter 12
Artwork: Chapter 13
Images: Plate Captions
Images: Image Captions
Appendix: Web Addresses

This Word document requires Microsoft Word to view. If your computer is unable to view Word documents, you can download the free reader from Microsoft.


  • Provides comprehensive coverage of bioinformatics, including sequence analysis, biological databases, pattern recognition, and applications to genomics, microarrays and proteomics
  • Places bioinformatics in the context of evolutionary biology, giving detailed treatments of molecular evolution and molecular phylogenetics and discussing evolution at the whole-genome level
  • Emphasizes the theoretical and statistical methods used in bioinformatics programs in a way that is accessible to biological science students
  • Features end-of-chapter problems and periodic self-tests to help students synthesize and absorb the material
  • Devoted website,, contains downloadable sequences, links to web resources, all answers to self-tests, and all art in JPEG and PowerPoint formats