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Bioinorganic Chemistry: A Short Course



Bioinorganic Chemistry: A Short Course

Rosette M. Roat-Malone

ISBN: 978-0-471-46148-7 April 2003 368 Pages

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A thorough, accessible guide for students of bioinorganic chemistry
Bioinorganic chemical knowledge grows more interesting and more complex with each passing year. As more details about the usage and utility of metals in biological species and more mechanistic and structural information about bioinorganic molecules becomes available, scientists and students continue to turn their attention to this blossoming discipline. Rosette Roat-
Malone's Bioinorganic Chemistry: A Short Course provides an accessible survey of bioinorganic chemistry for advanced undergraduate and graduate students. Comprehensive coverage of several topics offers insight into the increasingly diverse bioinorganic area.
Roat-Malone's text concentrates on bioinorganic chemistry's two major focuses: naturally occurring inorganic elements and their behavior in biological systems, and the introduction of inorganic elements into biological systems, often as medicines. The book begins with two review chapters, Inorganic Chemistry Essentials and Biochemistry Fundamentals. Chapter 3, Instrumental and Computer-Based Methods, provides an introduction to some important instrumental techniques, including basic information about computer hardware and software. Chapters on specific topics include:
* Iron Containing Oxygen Carriers and Their Synthetic Models
* Copper Enzymes
* The Enzyme Nitrogenase
* Metals in Medicine
The author also encourages instructors and students to pursue their own independent investigations in bioinorganic topics, providing a helpful, detailed list of suggestions. With a host of current bibliographic references, Bioinorganic Chemistry: A Short Course proves the premier text in its field.


1 Inorganic Chemistry Essentials.

1.1 Introduction.

1.2 Essential Chemical Elements.

1.3 Metals in Biological Systems: A Survey.

1.4 Inorganic Chemistry Basics.

1.5 Biological Metal Ion Complexation.

1.6 Electronic and Geometric Structures of Metals in Biological Systems.

1.7 Bioorganometallic Chemistry.

1.8 Electron Transfer.

1.9 Conclusions.


2 Biochemistry Fundamentals.

2.1 Introduction.

2.2 Proteins.

2.3 Nucleic Acids.

2.4 Zinc-Finger Proteins.

2.5 Conclusions.


3 Instrumental and Computer-Based Methods.

3.1 Introduction.

3.2 X-Ray Absorption Spectroscopy (XAS) and Extended X-Ray Absorption Fine Structure (EXAFS).

3.3 X-Ray Crystallography.

3.4 Electron Paramagnetic Resonance.

3.5 Nuclear Magnetic Resonance.

3.6 Mo?ssbauer Spectroscopy.

3.7 Other Instrumental Methods.

3.8 Introduction to Computer-Based Methods.

3.9 Computer Hardware.

3.10 Molecular Modeling and Molecular Mechanics.

3.11 Quantum Mechanics-Based Computational Methods.

3.12 Computer Software for Chemistry.

3.13 World Wide Web Online Resources.

3.14 Summary and Conclusions.


4 Iron-Containing Oxygen Carriers and Their Synthetic Models.

4.1 Introduction.

4.2 Myoglobin and Hemoglobin Basics.

4.3 Structure of the Prosthetic Group.

4.4 Analytical Techniques.

4.5 Mechanism for Reversible Binding of Dioxygen and Cooperativity of Oxygen Binding.

4.6 Behavior of Dioxygen Bound to Metals.

4.7 Structure of the Active Site in Myoglobin and Hemoglobin: Comparison to Model Compounds.

4.8 Model Compounds.

4.9 Binding of CO to Myoglobin, Hemoglobin, and Model Compounds.

4.10 Conclusions.


5 Copper Enzymes.

5.1 Introduction, Occurrence, Structure, Function.

5.2 Discussion of Specific Enzymes.

5.3 Model Compounds.

5.4 Conclusions.


6 The Enzyme Nitrogenase.

6.1 Introduction.

6.2 Detailed Mechanistic Studies.

6.3 Iron-Sulfur Clusters.

6.4 Fe-Protein Structure.

6.5 MoFe-Protein Structure.

6.6 Nitrogenase Model Compounds.

6.7 Conclusions.


7 Metals in Medicine.

7.1 Introduction.

7.2 Therapeutic Compounds.

7.3 Diagnostic Agents.

7.4 Metal Transport and Metallochaperones.

7.5 Metals in Medicine (MIM).


"...explain[s] the principle of bioinorganic chemistry and the nature of bioinorganic research in a lively and interesting way..." (Angewandte Chemie, Vol 42(48), 2003)

"...has the potential to stimulate interest and excitement in the reader..."(The Biochemist, 12 March 2003)

"A must for any serious student of the topic...highly recommended..." (Choice, Vol. 40, No. 9, May 2003)

"...a valuable resource for workers in the field." (Clinical Chemistry, Vol. 49, No. 9, 2003)

"...a solid addition to the available textbooks for courses in bioinorganic chemistry..." (Quarterly Review of Biology, September/November 2003)