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Biomarkers in Cancer Screening and Early Detection



Biomarkers in Cancer Screening and Early Detection

Sudhir Srivastava (Editor)

ISBN: 978-1-118-46882-1 June 2017 Wiley-Blackwell 320 Pages


Prepared by world leaders on this topic, Biomarkers in Cancer Screening and Early Detection offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers, from their discovery and development to their validation, clinical utility, and use in developing personalized cancer treatment.

  • Offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers
  • Provides immediately actionable information – and hopefully also inspiration – to move discovery and clinical application forward
  • Offers vital knowledge to help develop personalized cancer treatment for individual patients with specific cancers

List of Contributors, ix

Preface, xiii

Part I Foundations of Biomarker Research

1 Nuts and Bolts of Biomarker Research, 3
Sharmistha Ghosh and Sudhir Srivastava

2 Cancer Genome Methylation: Biology, Biomarker and Therapeutic Opportunities, 16
Shashwat Sharad, Taduru Sreenath, Shiv Srivastava, and Albert Dobi

3 MicroRNA Biomarkers for Early Detection of Cancer, 27
WendyWang, Matthew R Young, and Sudhir Srivastava

4 Inflammation and Cancer, 37
Pamela L Beatty, Sandra Cascio, and Olivera J Finn

5 Exosomes: A Valuable Biomedical Tool in Biomarker Discovery and Development, 50
Jocelyn Lee, Sharmistha Ghosh, and Sudhir Srivastava

6 Epithelial-to-Mesenchymal Transition (EMT): Clinical Implications, 64
Elisa CWoodhouse and Suresh Mohla

Part II State-of-the-Science in Organ-Specific Biomarker Research

7 Breast Cancer, 77
Benjamin A Katchman, Christos Patriotis, and Karen S Anderson

8 Ovarian Cancer, 93
Christos Patriotis, Archana Simmons, Karen H Lu, Robert C Bast, Jr, and Steven J Skates

9 Esophageal Cancer Biomarkers, 104
Yanxin Luo, Kishore Guda, SanfordD Markowitz, Amitabh Chak, Andrew M Kaz, andWilliam M Grady

10 Predictive Biomarkers for Therapy in Adenocarcinoma of the Upper Digestive Tract, 118
Heath D Skinner, Qiongrong Chen, Elena Elimova, RoopmaWadhwa, Shumei Song, and Jaffer A Ajani

11 Pancreatic Cancer, 130
Sam CWang and Peter J Allen

12 Colon Cancer, 141
Paul DWagner

13 Prognostic and Predictive Biomarkers for Colorectal Cancer, 151
Upender Manne, Balananda-Dhurjati Kumar Putcha, Temesgen Samuel, and Sudhir Srivastava

14 Early Detection of Lung Cancer, 163
Mohamed Hassanein, Melinda C Aldrich, Stephen A Deppen, Karl E Krueger, Eric L Grogan, and Pierre P Massion

15 Commonalities in Lung Cancer and COPD, 185
MalgorzataWojtowicz and Eva Szabo

16 Prostate Cancer, 197
Jacob Kagan, Ian M Thompson, and DanielWChan

Part III Biomarkers, Screening and Precision Health: Implications for Public Health

17 Improving the Clinical Validity of Biomarker Research in Cancer Detection, 209
David F Ransohoff

18 Cancer Overdiagnosis, Ramifications and Research Strategies, 220
Barbara K Dunn and Barnett S Kramer

19 Predictive Markers and Driver Genes From Treatment Trials: Potential Utility For Early Diagnosis, 231
Brian S Sorg, Sarfraz Memon, Kelly Y Kim, Aniruddha Ganguly, Tracy Lively, James Tricoli, Magdalena Thurin, Lokesh Agrawal, Tawnya C McKee, Barbara A Conley, and J Milburn Jessup

20 Statistical Consideration in Predictive and Prognostic Markers, 245
Fei Ye and Yu Shyr

21 Clinical Validation of Molecular Biomarkers in Translational Medicine, 256
Harry B Burke and William E Grizzle

22 Cancer Biomarker Assays: Performance Standards, 267
Anna K Fuzery and Daniel W Chan

23 Bioethics and Cancer Biomarker Research, 277
Nathan Nobis, William Grizzle, and Stephen Sodeke

24 Colon Cancer Screening, 283
Molly Perencevich, Jennifer Inra, and Sapna Syngal