Skip to main content

Biomedical Applications of Proteomics

Biomedical Applications of Proteomics

Jean-Charles Sanchez (Editor), Garry L. Corthals (Editor), Denis F. Hochstrasser (Editor)

ISBN: 978-3-527-60583-5

Mar 2006, Wiley-Blackwell

452 pages

$263.99

Description

In this first book to provide an overview of applications of proteomics in the discovery of new diagnostic, prognostic and therapeutic targets, a team of international specialists from research institutions, hospitals and companies contribute with their specific expertise. They cover a wide range of example applications for the most important diseases, such as heart and cardiovascular disorders, cancer, pharmatoxicology, infectious diseases and diseases of the nervous system.
Denis Hochstrasser is an eminent scientist in the field of bioinformatics and proteomics and one of the founders of the Swiss Prot Databank as well as of the Swiss biotech company Genebio.

Preface
SECTION I: ASPECTS OF BIOMEDICAL RESEARCH
Proteomics in Biomedicine -
A Tool, a Science or an Art?
SECTION II: BLOOD VESSELS
Antibody-Based Vascular Targeting: Proteomic Techniques for the Identification and Quantitation of Membrane Proteins on Endothelial Cells
Vasculature, Vascular Disease and Atherosclerosis
Discovery of New Diagnostic Markers of Stroke
SECTION III: CANCER
Unravelling Biological Pathways and the Identification of Clinical Markers and Targets in Renal Cancer
HSP27 in Cancer
Proteomic Approaches for Biomarker Discovery in Colorectal Cancer
Clinical Proteomics: Ovarian Cancer
Protein Expression Profiling Analysis in Hematopoietic Stem Cells: Phenotypic Characterization of Mesenchymal Stem Cells
Lymphoblastoid and Lymphoma Cells
SECTION IV: PHARMACO-TOXICOLOGY
Chemoresistance in Cancer Cells
Diabetes Mellitus: Complex Molecular Alterations)
SECTION V: INFECTIOUS DISEASES
Proteome Approach to Infectious Diseases
New Insights Into HIV Lymphocyte Infection
Modifications of Host-Cell Proteomes Induced by Herpes Virus Type 1
Francisella Tularensis
SECTION VI: CENTRAL NERVOUS SYSTEM
Proteomics in Clinical Neurosciences
Human Cerebrospinal Fluid
Proteomic Applications for Molecular Assessment of Alzheimer's Disease
SECTION VII: MASS SPECTROMETRY AND BIOINFORMATICS
MALDI MS Imaging in Biomedical Research
Protein Variations: Resources and Tools
"In spite of the complexity of many diseases as well as proteomic approaches that may be applied, the style of the book is generally clear and straightforward in its presentation."
Proteomics

"This book is a good reference resource for all academic and other researchers who are interested in how proteomics is applied in biomedicine."
E-STREAMS

"... a nice overview of biomedical proteomics applications."
Clinical Chemistry

"...those new to the field can use the book to quickly catch up on applications of proteomics. ... the book [is also] a great resource for literature and techniques."
Environmental Health Perspectives

"...this book is a compendium of biomedical publications covering a wide range of state-of-the-art proteomic techniques and aimed to give a detailed view what current proteomic technologies can serve for in biomedical research. The clear style of the book and its straightforward presentations provides profound insight to scientists. Furthermore, it serves as a good resource for literature and techniques for academic and other researchers interested in the implementation of proteomics in biomedicine. (...) Overall the editors provide a comprehensive overview on biomedical proteomics applications for both, protein analysts familiar with state-of-the-art proteome technologies as well as physicians in molecular medicine."
Arneimittel-Forschung/Drug Research