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Biomedical Nanostructures

Biomedical Nanostructures

Kenneth Gonsalves (Editor), Craig Halberstadt (Editor), Cato T. Laurencin (Editor), Lakshmi Nair (Editor)

ISBN: 978-0-470-18582-7

Nov 2007

450 pages

$148.99

Description

Learn to Use Nanoscale Materials to Design Novel Biomedical Devices and Applications

Discover how to take full advantage of nanoscale materials in the design and fabrication of leading-edge biomedical devices. The authors introduce you to a variety of possible clinical applications such as drug delivery, diagnostics, and cancer therapy. In addition, the authors explore the interface between micron and nanoscale materials for the development of applications such as tissue engineering. Finally, they examine the mechanisms of cell interactions with material surfaces through the use of nanotechnology-based material processing and characterization methods.

The text's three sections highlight its interdisciplinary approach:
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Part One: Nanostructure Fabrication
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Part Two: Bio-Nano Interfaces
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Part Three: Clinical Applications of Nanostructures

Among the key topics covered are nanotechnology in tissue regeneration; biomolecular engineering; receptor-ligand interactions; cell-biomaterial interactions; nanomaterials in diagnostics, drug delivery, and cancer therapy; and nano- and micron-level engineering and fabrication.

Throughout the text, clear examples guide you through the chemistry and the processing involved in designing and developing nanoscale materials for biomedical devices. Each chapter begins with an introduction and ends with a conclusion highlighting the key points. In addition, references at the end of the chapter help you expand your research on any individual topic. In summary, this book helps biomedical researchers and engineers understand the physical phenomena that occur at the nanoscale in order to design novel cell-based constructs for a wide range of applications.
PART I. NANOSTRUCTURE FABRICATION.

1. Nanofabrication Techniques.

2. Micro/ Nano-Machining and Fabrication of Materials for Biomedical Applications.

3. Novel Nanostructures as Molecular Nanomotors.

4. Bioconjugation of Soft Nanomaterials.

5. Nanotechnology and Drug Delivery.

6. Polymeric NanoParticles and Nanopore Membranes for Controlled Drug and Gene Delivery .

7. Development of Nanostructures for Drug Delivery Applications.

8. Bioconjugated Nanoparticles for Ultrasensitive Detection of Molecular Biomarkers and Infectious Agents.

PART II. BIO-NANO INTERFACES.

9. ECM Interactions With Cells From The Meso To NanoScale.

10. Cell Behavior Towards Nanostructured Surfaces.

11. Cellular Behavior on Basement Membranes Inspired Topographically Patterned Synthetic Matrices.

12. Focal Adhesions: Self-Assembling Nanoscale Mechanochemical Machines that Control Cell Function.

13. Controlling Cell Behavior via DNA and RNA Transfections.

14. Multi-Scale Co-Culture Models for Orthopaedic Interface Tissue Engineering.

PART III. CLINICAL APPLICATIONS OF NANOSTRUCTURES.

15. Nanostructures for Tissue Engineering/Regenerative Medicine.

16. Nanostructures for Cancer Therapy.

17. Clinical Applications of Micro-and NanoScale Biosensors.

18. Nanoscale Iron Compounds Related to Neurodegenerative Disorders.

19. Application of Nanotechnology into Life Science: Benefit or Risk.

""...the book is a fruitful source of information and it is enjoyable to read thanks to nice illustrations. It will be of interest not only to students or scientists not familiar with these fields, but also to specialists, because of the large number of references, many as recent as 2006."" (Macromol. Chem. Phys. 04/2008)
  • Funding for research into the medical and biological applications of nanotechnology has exploded over recent years
  • Explores the integration across interfaces and size scales from nano to micro, an area that is often overlooked and/or misunderstood