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Biopharmaceuticals: Biochemistry and Biotechnology, 2nd Edition

Biopharmaceuticals: Biochemistry and Biotechnology, 2nd Edition

Gary Walsh

ISBN: 978-1-118-68738-3

Apr 2013, Wiley-Blackwell

544 pages



The latest edition of this highly acclaimed textbook, provides a comprehensive and up-to-date overview of the science and medical applications of biopharmaceutical products. Biopharmaceuticals refers to pharmaceutical substances derived from biological sources, and increasingly, it is synonymous with 'newer' pharmaceutical substances derived from genetic engineering or hybridoma technology.

This superbly written review of the important areas of investigation in the field, covers drug production, plus the biochemical and molecular mechanisms of action together with the biotechnology of major biopharmaceutical types on the market or currently under development. There is also additional material reflecting both the technical advances in the area and detailed information on key topics such as the influence of genomics on drug discovery.

Chapter 1. Pharmaceuticals, biologies and biopharmaceuticals.

Chapter 2. The drug development process.

Chapter 3. The drug manufacturing process.

Chapter 4. The cytokines—the interferon family.

Chapter 5. Cytokines: interleukins and tumour necrosis factor.

Chapter 6. Haemopoietic growth factors.

Chapter 7. Growth factors.

Chapter 8. Hormones of therapeutic interest.

Chapter 9. Blood products and therapeutic enzymes.

Chapter 10. Antibodies, vaccines and adjuvants.

Chapter 11. Nucleic acid therapeutics.

Appendix 1. Biopharmaceuticals thus far approved in the USA or European Union.

Appendix 2. Some Internet addresses relevant to the biopharmaceutical sector.

Appendix 3. Two selected monographs reproduced from the European Pharmacopoeia with permission from the European Commission:  I. Products of recombinant DNA Technology; II. Interferon a -2 concentrated solution.

Appendix 4. Manufacture of biological medicinal products for human use. (Annex 2 from The Rules Governing Medicinal Products in the European Community, Vol. 4, Good Manufacturing Practices for Medicinal Products).


Extensively revised and updated, the Second Edition discusses the latest developments in the field, providing a greater focus on actual commercial products and how they are manufactured. Substantial new sections on detailing biopharmaceutical drug delivery and how advances in genomics and proteomics will impact upon (bio)pharmaceutical drug development are also included.
"…contains just about everything that anyone would want to know about the subject…It's all here in this easy-to-read textbook.” (Biochemistry and Molecular Education, March/April 2004)

"...well written… (and) copiously illustrated..." (Chemistry & Industry, 17th January 2005)

 “This book should be recommended reading for all under-graduate course in pharmacy and the pharmaceutical sciences …”. (Cell Biochemistry & Function, March-April 2005)

  • One of the first key textbooks on the market to comprehensively outline the science of the biopharmaceutical industry.
  • Provides an extensive, up-to-date overview of the science and medical applications of biopharmaceutical products.
  • Includes additional relevant material to reflect the recent technological advances in the subject and also includes a new section on the impact of genomics on drug discovery