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Biophysical Analysis of Membrane Proteins: Investigating Structure and Function

Biophysical Analysis of Membrane Proteins: Investigating Structure and Function

Eva Pebay-Peyroula (Editor)

ISBN: 978-3-527-31677-9

Dec 2007

368 pages

In Stock

$265.95

Description

Meeting the need for a book on developing and using new methods to investigate membrane proteins, this is the first of its kind to present the full range of novel techniques in one resource. Top researchers from around the world focus on the physical principles exploited in the different techniques, and provide examples of how these can bring about important new insights.
Following an introduction, further sections discuss structural approaches, molecular interaction and large assemblies, dynamics and spectroscopies, finishing off with an exploration of structure-function relationships in whole cells.
Introduction
STRUCTURAL APPROACHES
Membrane Protein Structure Determination by Electron Cryo-microscopy
NMR Liquid or Solid State
MOLECULAR INTERACTION AND LARGE ASSEMBLIES
Analytical Ultracentrifugation: Membrane Protein Assemblies in the Presence of Detergent
SPR Biosensors for Characterizing Membrane-associated Proteins
Atomic Force Microscopy (AFM): High Resolution Imaging of Structure and Assembly of Membrane Proteins
DYNAMICS
Molecular Dynamics Simulations
Understanding Structure and Function of Membrane Proteins Using Free Energy Calculations
Neutron Scattering to Study Membrane Structure and Dynamics
SPECTROSCOPIES
Circular Dichroism: Folding and Conformational Changes of Membrane Proteins
Membrane Protein Structure and Conformational Change Probed Using Fourier Transform Infrared Spectroscopy
Raman Spectroscopy on Light Harvesting Complex
EXPLORING STRUCTURE-FUNCTION RELATIONSHIPS IN WHOLE CELLS
Energy Transfer Technologies to Monitor the Dynamics and Signaling Properties of G-protein Coupled Receptors in Living Cells
""...exemplified by the respective author’s own studies…"" (Wiley-VCH - ChemBioChem)