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Bioregenerative Engineering: Principles and Applications



Bioregenerative Engineering: Principles and Applications

Shu Q. Liu

ISBN: 978-0-471-70907-7 April 2007 1104 Pages


A unique, comprehensive reference that integrates the molecular, cellular, physiological, pathological, and engineering aspects of regenerative processes

Bioregenerative engineering is an emerging discipline based on applying engineering principles and technologies to regenerative medicine. It induces, modulates, enhances, and/or controls regenerative processes by using engineering approaches to improve the restoration of the structure and function of disordered or lost molecules, cells, tissues, and organs. This reference systematically summarizes bioregenerative engineering principles, technologies, and current research to help scientists understand biological regeneration and design new therapeutic strategies. Succinct and well-organized with a detailed table of contents to help readers pinpoint information, this reference:

Provides the fundamental theory and principles of molecular, cellular, and tissue regenerative engineering concurrently with experimental approaches

Presents the foundations of bioregenerative engineering, encompassing the molecular basis, the regulatory mechanism of regeneration, and the developmental aspects

Combines molecular and cell biology with potential applications

Addresses experimental design, methods, and modeling at the molecular/cellular/tissue levels

Covers the general mechanisms and technologies of bioregenerative engineering, as well as its application to the treatment of human disorders

Discusses the engineering tests and therapies for major organ systems

Presenting an in-depth introduction to the biological and engineering aspects of the field and an up-to-date overview of current research, this is a one-of-a-kind resource for scientific researchers and medical practitioners, as well as for graduate and undergraduate students in biomedical engineering, bioengineering, chemical engineering, molecular biology, and cell biology.



Section 1. Molecular Basis for Bioregenerative Engineering.

Chapter 1. Structure and Function of Macromolecules.

Chapter 2. Regulation of Gene Expression.

Chapter 3. Structure and Function of Cellular Components.

Chapter 4. Extracellular Matrix.

Section 2. Regulatory Mechanisms of Regeneration.

Chapter 5. Cell Signaling Pathways and Mechanisms.

Chapter 6. Fundamental Cellular Functions.

Section 3. Developmental Aspects of Bioregenerative Engineering.

Chapter 7. Fertilization and Early Embryonic Development.

Chapter 8. Embryonic Organ Development.

Chapter 9. Regeneration of Adult Cells, Tissues, and Organs.


Section 4. Principles of Bioregenerative Engineering.

Chapter 10. Molecular Aspects of Bioregenerative Engineering.

Chapter 11. Cell and Tissue Regenerative Engineering.

Chapter 12. Biomaterial Aspects of Bioregenerative Engineering.

Section 5. Application of Bioregenerative Engineering to Organ Systems.

Chapter 13. Nervous Regenerative Engineering.

Chapter 14. Cardiac Regenerative Engineering.

Chapter 15. Vascular Regenerative Engineering.

Chapter 16. Pulmonary Regenerative Engineering.

Chapter 17. Liver Regenerative Engineering.

Chapter 18. Gastrointestinal Regenerative Engineering.

Chapter 19. Pancreatic Regenerative Engineering.

Chapter 20. Urinary Regenerative Engineering.

Chapter 21. Skeletal Muscle Regenerative Engineering.

Chapter 22. Bone and Cartilage Regenerative Engineering.

Chapter 23. Ocular Regenerative Engineering.

Chapter 24. Skin Regenerative Engineering.

Chapter 25. Regenerative Engineering for Cancer.


  • Integrates biochemical, physiological, and engineering into a single text
  • Provides the fundamental theory concurrently with experimental approaches
  • Combines molecular biology with potential applications, which should interest engineering students
  • Sets an important foundation for presenting the fundamental concepts of molecular, cellular, and tissue engineering – especially important because engineering students lack a background in biochemistry, physiology, and cell biology
  • Addresses experimental design, methods, and modeling at the molecular/cellular/ tissue levels. A common problem for students and researchers is to perceive the mechanisms at these levels and design a successful project. Integrating experimental aspects with teaching material will improve the understanding of fundamentals
  • Fills a gap in the field, where there is a lack of an “adequate” textbook on tissue engineering
  • Contains exercises at the end of each chapter, and the author will provide a solutions manual for academic adopters
  • All figures will appear in color on the Internet