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Bioseparation and Bioprocessing: A Handbook

Bioseparation and Bioprocessing: A Handbook

Ganapathy Subramanian (Editor)

ISBN: 978-3-527-61964-1

Apr 2008

1052 pages

Select type: O-Book

Description

Rapid developments in biotechnology create a demand for practical, up-to-date reviews written by and for experts in industry. This compact handbook provides all relevant up-to-date information on important bioseparation and bioprocessing techniques that are actively applied in the biotechnology industries. The handbook presents an applications-orientated overview on
  • case studies and general strategies for quality control and characterization
  • detailed guidelines on developing economic and technically feasible bioseparation schemes
  • strategies and methods for intracellular bioproduct release
  • chromatographic and membrane downstream processes used in biotechnology
  • applications of modern non-invasive methods such as neural networks for on-line estimation and control of fermentation variables on an industrial scale
  • a practical, commercially-relevant guide to biosafety
  • and many more aspects which are indispensible for present and future industrial success.

2 Volume Set: Volume I: Biochromatography - Membrane Separations - Modeling - Validation; Volume II: Processing - Quality and Characterisation - Economics, Safety and Hygiene

VOLUME I:

PART ONE: BIOCHROMATOGRAPHY
Simulated moving bed (SMB): some possible applications for biotechnology
Systematic development of chromatographic processes using perfusion chromatography technology
Hydrophobic interaction chromatography of proteins
Displacement chromatography: application to downstream processing in biotechnology
Affinity chromatography
Large scale chromatography: design and operation
Radial flow chromatography: developments and application in bioseparations
Enhanced diffusion chromatography and related sorbents for biopurification
Expanded bed adsorption chromatography
PART TWO: MEMBRANE SEPARATIONS
Application of membrane bioseparation processes in the beverage and food industries
Recovery of biological products by liquid emulsion membranes
Membranes modified for biochromatography
PART THREE: MODELING
Computer modeling of chromatographic bioseparation
Neural network applications to fermentation processes
Advances in modeling for bioprocess supervision and control
PART FOUR: VALIDATION
Validation of viral safety for pharmaceutical proteins
Validation issues in chromatographic processes

VOLUME II:

PART ONE: PROCESSING
Strategies in downstream processing
Protein stability in downstream processing
Production of transgenetic protein
Harvesting recombinant protein inclusion bodies
Application of glycobiology for the generation of recombinant glycoprotein therapeutics
The release of intracellular bioproducts
Microcarriers in cell culture production
Purification and characterisation of monoclonal antibodies
PART TWO: QUALITY AND CHARACTERISATION
Biological standardisation of interferons and other cytokines
The strategic role of assays in process development: A case study of matrix assisted laser desorption ionisation mass spectroscopy as a tool for bioparmaceutical development
Quality control of protein primary structure by automated sequencing and mass spectrometry
General strategies for the characterization of the carbohydrates of recombinant glycoprotein therapeutics
PART THREE: ECONOMICS, SAFETY AND HYGIENE
Biosafety
Process hygiene in production chromatography and bioseparation
Strategies and considerations for advanced economy in downstream processing of biopharmaceutical proteins
The editor has done an excellent job in bringing together such a comprehensive group of authors all of whom have a great deal of expertise in their own particular fields. All the chapters are well written and give a balanced critique of the subject in a clear and readable style. These two volumes provide a good basis for understanding the requirements of separation/purification in biotechnology and options available when designing a strategy. It is recommended reading for all those involved in biotechnology who need to appreciate the problems associated with obtaining a commercially viable product.
BIOSEPARATION