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Biotechnology, A Multi-Volume Comprehensive Treatise, Volume 3, Bioprocessing, 2nd, Completely Revised Edition

Biotechnology, A Multi-Volume Comprehensive Treatise, Volume 3, Bioprocessing, 2nd, Completely Revised Edition

Gregory Stephanopoulos (Volume Editor), Hans-Jürgen Rehm (Editor), Gerald Reed (Editor), Alfred Pühler (Associate Editor), Peter Stadler (Associate Editor)

ISBN: 978-3-527-62084-5

May 2008, Wiley-Blackwell

831 pages

Select type: O-Book

Description

Bioprocessing: an exciting new engineering discipline. It combines the development and optimization of biotechnological processes with effective strategies to recover and purify the desired products. Safety as well as cost play an important role here.
This volume covers the immensely differentiated spectrum of techniques and operations of bioprocessing, presented by the most competent experts in the field. An overview of upstream and downstream processing is given, fermentation and cell culture processes and the design of microbial fermenters are presented. A closing group of chapters is dedicated to issues of process validation, measurement, and regulation.
Topics included are: Industrial Cell Cultures/ Pharmaceutical Proteins/ Bioreactors/ Media and Air Sterilization/ Oxygen Transfer/ Scale Implications/ Fermentation Data Analysis/ Cell and Debris Removal/ Protein Purification/ Electrokinetic Separations/ Final Recovery Steps/ Process Validation
Partial table of contents:

NATURE AND ISSUES OF BIOPROCESSING.

Fermentation -An Overview.

Overview of Downstream Processing.

PRODUCT RECOVERY AND PURIFICATION.

Cell and Cell Debris Removal.: Centrifugation and Crossflow Filtration.

Cell Disruption and Isolation of Non-Secreted Productions.

PROCESS VALIDATION, REGULATORY ISSUES.

Analytical Protein Chemistry.

Treatment of Biological Waste.

Index.