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Biotechnology, A Multi-Volume Comprehensive Treatise, Volume 7, Products of Secondary Metabolism, 2nd, Completely Revised Edition

Biotechnology, A Multi-Volume Comprehensive Treatise, Volume 7, Products of Secondary Metabolism, 2nd, Completely Revised Edition

H. Kleinkauf (Volume Editor), Hans von Döhren (Volume Editor), Hans-Jürgen Rehm (Editor), Gerald Reed (Editor), Alfred Pühler (Associate Editor), Peter Stadler (Associate Editor)

ISBN: 978-3-527-62089-0

May 2008, Wiley-Blackwell

743 pages

Select type: O-Book

Description

Products of secondary metabolism from fermentation and cell culture are mainly pharmaceuticals, ranging from traditional antibacterials like beta-lactams, new generation compounds like dalbaheptides and lantibiotics to immunomodulators and antitumor drugs. The major fields of application of these low volume/high price products are human and veterinary medicine as well as plant protection. In this volume functionally based screening approaches and the applications of molecular genetics in the discovery and process improvement of compounds are emphasized. Along with the exploitation of new sources the growing understanding of biosynthetic processes permits the identification of the genetic backgrounds.

Topics included are: Novel Receptor-Active Compounds - Microbial Lipids - Microbial Siderophores - beta-Lactam Antibiotics - Peptide Antibiotics - Lantibiotics - Glycopeptide Antibiotics (Dalbaheptides) - Aminoglycosides - Products from Basidiomycetes - Cyclosporins - Secondary Products from Plant Cells - Antitumor Agents

General Aspects of Secondary Metabolism
Regulation of Bacterial Antibiotic Production
Screening of Novel Receptor-Active Compounds of Microbial Origin
Microbial Lipids
Microbial Siderophores
Advances in the Molecular Genetics of beta-Lactam Antibiotic Synthesis
Peptide Antibiotics
Lantibiotics
Glycopeptide Antibiotics (Dalbaheptides)
Aminoglycosides and Sugar Components in Other Secondary Metabolites
Products from Basidiomycetes
Cyclosporins: Recent Developments in Biosynthesis, Pharmacology and Biology, and Clinical Applications
Secondary Products from Plant Cell Cultures
Biotechnical Drugs as Antitumor Agents