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Blood-Brain Barriers: From Ontogeny to Artificial Interfaces

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces

Rolf Dermietzel (Editor), David C. Spray (Editor), Maiken Nedergaard (Editor)

ISBN: 978-3-527-61122-5

May 2007

774 pages

Select type: O-Book

Description

This first handbook to integrate developmental and cellular aspects combines the different structural and functional features involved in the regulation of brain perfusion and neuronal function. It highlights pharmacological and biomedical applications with sections on drug delivery and disease-related states as well as explaining in detail the role of astrocytes, shown to be an essential link between neurons and cerebral blood vessels. In addition the book studies how the structural elements interact in response to the dynamics of neuronal activities, necessitating adaptive mechanism of the interface. A significant part of the book describes new approaches to how the barrier can be surmised for drug delivery and how it can be mimicked by artificial in vitro systems for drug testing. Finally, the involvement of the barrier in brain diseases is considered, focusing on inflammatory and neurodegenerative disorders of the brain.
Covering basic knowledge as well as specific information dealing with very recent progress in blood-brain interface research, this book will be of interest to a broad audience.
Introductory Preface: The blood-brain interfaces: An integrated concept (R. Dermietzel, D. Spray, M. Nedergaard)
ONTOGENY OF THE BLOOD-BRAIN-BARRIER
Development of the Blood-Brain Interface (B. Engelhardt)
Brain Angiogenesis and Barrier Genesis (K.-W. Kim)
Microvascular Influences on Progenitor Cell Mobilization and Fate in the Adult Brain (S. Goldman)
THE CELLS OF THE BLOOD-BRAIN INTERFACE: REVISITED
The endothelial frontier (H. Wolburg)
Pericytes and their contribution to the blood-brain-barrier (M. Ramsauer)
Brain Macrophages: Enigmas and Conundrums (G.I. Hatton)
The microglial component (I. Bechmann)
The bipolar astrocyte (J. Abbott)
Responsive astrocytic endfeet: the role of AQP4 in BBB development and functioning (A. Frigeri
HORMONAL AND ENZYMATIC CONTROL OF BRAIN VESSELS
The Role of Fibroblast Growth Factor 2 in Establishment and Maintenance
of the Blood-brain Barrier (B. Reuss)
Cytokine interaction with the blood-brain-barrier (W. Pan)
Insulin and the blood-brain barrier (W.A. Banks)
Glucocorticoid Hormones and Estrogens: Their Interaction with the Endothelial Cells of the Blood-Brain Barrier (J.-B. Dietrich)
Metalloproteases and the brain microvasculature (D. Krause)
CULTURING THE BLOOD BRAIN BARRIER
Culturing the blood-brain-barrier (R. Cecchelli)
Induction of blood-brain barrier properties in cultured endothelial cells (H.-J. Galla)
Artificial blood brain barriers (D. Janigro)
In silico prediction models for blood-brain barrier permeation (G. Ecker)
DRUG DELIVERY TO THE BRAIN
The Blood-Brain Barrier: Roles of the Multidrug Resistance Transporter P-Glycoproteon (R. Beliveau)
Targeting of neuropharmaceuticals by chemical delivery (N. Bodor)
Drug Delivery to the Brain by Internalizing Receptors at the Blood-Brain Barrier (A.G. de Boer)
VASCULAR PERFUSION
Blood-Brain Transfer and Metabolism of Oxygen (A. Gjedde)
Functional Brain Imaging (G. Dienel)
DISEASE-RELATED RESPONSE
Inflammatory response of the blood-brain interface (P. Faustmann)
Stroke and the Blood-Brain Interface (M.J. Cipolla)
Diabetes and the consequences for the blood-brain barrier (A.D. Mooradian)
Human parasitic disease in the context of the blood-brain-barrier -
Effects, interactions, and transgression (D.A. Milner)
The healthy and diseased retina-blood interfaces (T. Chan-Ling)
""Das Handbuch verbindet grundlegendes Wissen mit dem aktuellen Stand der Forschung zur Blut-Hirn-Schranke ... ""
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