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CH-Activation for Asymmetric Synthesis

CH-Activation for Asymmetric Synthesis

Françoise Colobert, Joanna Wencel-Delord

ISBN: 978-3-527-81086-4

Feb 2020

240 pages

Select type: E-Book


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C-H activation in asymmetric synthesis is one of the most rapidly developing fields in organic chemistry. It opens a new way for accessing optive active compounds in an easy and effective way. This book presents this exciting field with all its facets.
I. Asymmetric activation of C(sp3)-H bonds
-C(sp3)-H bond insertion by metal carbenoids
-C-C bond formation
-C-N bond formation
-C-H activation as stereodiscriminant step
-Enantioselective Intramolecular couplings
-Enantioselective Intermolecular couplings
-Substrat-controlled transformation ? diastereoselective functionalization
-C-H activation followed by stereoselective functionalization
II. Stereoselective synthesis implying activation of C(sp2)-H bonds
-C(sp2)-H bond insertion by metal carbenoids
-C-H activation involved in stereodiscriminant step
-Planar chirality
-Axial chirality
-Non-stereoselective C-H activation followed by selective functionalization of metallacyclic intermediate
-Intramolecular couplings
-Intermolecular couplings