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Calcium Binding Proteins

Eugene Permyakov, Robert H. Kretsinger

ISBN: 978-1-118-09954-4 March 2011 598 Pages


Calcium Binding Proteins explains the unique and highly diverse functions of calcium in biology, which are realized by calcium binding proteins. The structures and physical characteristics of these calcium binding proteins are described, as well as their functions and general patterns of their evolution. Techniques that underlie the description of proteins are discussed, including NMR, circular dichroism, optical rotatory dispersion spectroscopy, calorimetry,and crystallography.  The book discusses the patterns of bochmical phenomena such as calcium homeostasis, mineralization, and cell signaling that involve specific proteins.  It summarizes ongoing research and presents general hypotheses that help to focus future research, and also provides a conceptual framework and a description of the underlying techniques that permits someone entering the field to become conversant.

1. Historical Perspective.

2. Physiological Processes Involving Calcium Binding Proteins.

3. Comparison of the Ca2+ Ion with Other Metal Cations.

4. Complexes of Calcium and Other Cations with Low Molecular Weight.

5. Stoichiometry, Kinetics, and Thermodynamics of Calcium Binding.

6. Experimental Methods Used to Study Calcium Binding to Proteins.

7. Structure and Evolution of Proteins.

8. Protein Complexes with Metals Other than Calcium.

9. Nonessential Metals.

10. Parvalbumin.

11. EF-Hand Proteins.

12. Cytosolic Calcium Binding Proteins Lacking EF-Hands.

13. Extracellular Calcium Binding Proteins.

14. Interactions of Calcium Binding Proteins with Other Metal Ions.

15. Interactions of Calcium Binding Proteins with Other Proteins and with Membranes.

16. Genetic Engineering of Calcium Binding Proteins.