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In this much anticipated first edition, the authors present the basic canons of first-year calculus, but motivated through real biological problems. The two main goals of the text are to provide students with a thorough grounding in calculus concepts and applications, analytical techniques, and numerical methods and to have students understand how, when, and why calculus can be used to model biological phenomena. Both students and instructors will find the book to be a gateway to the exciting interface of mathematics and biology.