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Capillary Electrophoresis - Mass Spectrometry (CE-MS): Principles and Applications



Capillary Electrophoresis - Mass Spectrometry (CE-MS): Principles and Applications

Gerhardus de Jong

ISBN: 978-3-527-69381-8 June 2016 368 Pages


This monograph offers the reader a complete overview on both principles and applications of CE-MS. Starting with an introductory chapter on detection in CE, also related and more specialized techniques such as electrophoretic and chromatographic preconcentration are discussed. A special emphasis is put on CE-MS interfaces, which are described in detail. In a separate chapter, attention is paid to sheath-liquid interfacing. The developments and possibilities of microchip CE-MS are also described. Applications to all relevant areas are discussed in distinct chapters, each written by experts in the respective fields.
Besides applications in pharmaceutical analysis and bioanalysis, recent implementations in food science, forensic analysis, analysis of intact proteins, metabolomics and proteomics are highlighted. MS is a perfectly appropriate detection system for CE, as efficient separation is coupled to sensitive and selection detection. Moreover, MS can provide structure information on the separated compounds. CE-MS has now been developed into a strong hyphenated system complementary to LC-MS. This monograph is an unique source of knowledge for everyone dealing with and interested in CE-MS.

Detection in Capillary Electrophoresis - An Introduction

Electrospray Ionization Interface Development for Capillary Electrophoresis-Mass Spectrometry

Sheath Liquids in CE-MS: Role, Parameters, and Optimization

Recent Developments of Microchip Capillary Electrophoresis Coupled with Mass Spectrometry

On-line Electrophoretic, Electrochromatographic, and Chromatographic Sample Concentration in CE-MS

CE-MS in Drug Analysis and Bioanalysis

Intact Protein Analysis by Capillary Electrophoresis - Mass Spectrometry

CE-MS in Food Analysis and Foodomics

CE-MS in Forensic Sciences with Focus on Forensic Toxicology

CE-MS in Metabolomics

CE-MS for Clinical Proteomics and Metabolomics: Strategies and Applications

"Overall, this book presents the most comprehensive overview on state-of-the-art CE-MS and will surely help to further spread the technique...Even with more than 10 years’ experience in CE and CE-MS, I personally profited from reading the book, especially from the instrumentally oriented chapters. I can recommend the book to all CE and CE-MS users to broaden their scope of applications and refresh their knowledge on the state of the art." (Carolin Huhn for Analytical and Bioanalytical Chemistry 11/03/2017)