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Carbohydrates in Chemistry and Biology: A Comprehensive Handbook

Carbohydrates in Chemistry and Biology: A Comprehensive Handbook

Beat Ernst (Editor), Gerald W. Hart (Editor), Pierre Sinaÿ (Editor)

ISBN: 978-3-527-61825-5

Apr 2008

2578 pages

Select type: O-Book

Description

Carbohydrate Chemistry and Glycobiology have witnessed a rapid expansion during the last few years with the development of numerous new, imaginative and efficient syntheses which provide further insight into structures and biological interactions of glycoconjugates. Glycosylation reactions are widely used in the synthesis of pharmaceuticals and bio-active compounds. In biology and medicine oligosaccharides play a central role in immuno-stimulation, cancer or allergic responses. Glycoscience is a very instructive example of how one common topic of interest stimulates both chemistry and biology to collectively open scientific frontiers.

This synergy is made visible in this work. Three leading experts in the fields of Glycochemistry and Glycobiology have invited numerous renowned authors to provide a comprehensive overview of the recent advances and findings in Glycoscience. This four-volume handbook presents an integrated and cutting-edge view, and covers all chemical aspects, such as syntheses and analysis of carbohydrates and oligosaccharides, as well as the biological role and activity of oligosaccharides and carbohydrate/protein interactions.

Partial Table of Content.

CHEMICAL SYNTHESIS OF GLYCOSIDES.

Trichloroacetimidates (R. Schmidt & K.-H. Jung).

Iterative Assembly of Glycals and Glycal Derivatives: The Synthesis of Glycosylated Natural Products and Complex Oligosaccharides (L. Williams, et al.).

Thioglycosides (S. Oscarson).

Glycosylation Methods: Alkylations of Reducing Sugars (J. Tamura).

Other Methods of Glycosylation (L. Panza & L. Lay).

Glycolipid Synthesis (H. Ishida).

Special Problems in Glycosylation Reactions: 2-Deoxy Sugars (A. Veyrières).

Orthogonal Strategy in Oligosaccharide Synthesis (O. Kanie).

Intramolecular Glycosidation Reactions (J. Madsen & M. Bols).

SYNTHESIS OF OLIGOSACCHARIDE MIMICS.

Saccharide-Peptide Hybrids (H. Wessel).

Index.

"a very useful collection of mostly excellent overviews" (Angewandte Chemie, International Edition 19 November 2001)