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Catalytic Asymmetric Conjugate Reactions

Catalytic Asymmetric Conjugate Reactions

Armando Cordova (Editor)

ISBN: 978-3-527-63209-1

Dec 2010

464 pages



This unique and long-awaited handbook on this important topic in the hot field of stereoselective organic synthesis covers several types of nucleophiles. Top international authors deal with modern forms of achieving stereoselective conjugate additions based on the use of chiral auxiliaries or asymmetric catalysis, such as P-N ligands, organocatalysis, domino reactions, Lewis acid and base catalysis. There is also a discussion of the employment of enantioselective conjugate addition transformations in total synthesis of important molecules. With its reliable and previously unpublished experimental procedures, this is a true source of high quality information.
1 Rhodium- and Palladium-Catalyzed Asymmetric Conjugate Additions
2 Cu- and Ni-Catalyzed Conjugated Additions of Organozincs and Organoaluminums to a,ß-Unsaturated Carbonyl Compounds
3 ECAs of Organolithium Reagents, Grignard Reagents, and Examples of Cu-Catalyzed ECAs
4 Asymmetric Bifunctional Catalysis Using Heterobimetallic and Multimetallic Systems in Enantioselective Conjugate Additions
5 Enamines in Catalytic Enantioselective Conjugate Additions
6 Iminium Activation in Catalytic Enantioselective Conjugate Additions
7 Organocatalytic Enantioselective Conjugate Additions of Heteroatoms to a,ß-Unsaturated Carbonyl Compounds
8 Domino Reactions Involving Catalytic Enantioselective Conjugate Additions
9 Asymmetric Epoxidations of a,ß-Unsaturated Carbonyl Compounds
10 Catalytic Asymmetric Baylis?Hillman Reactions and Surroundings