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Cellular Signal Transduction in Toxicology and Pharmacology: Data Collection, Analysis, and Interpretation

Cellular Signal Transduction in Toxicology and Pharmacology: Data Collection, Analysis, and Interpretation

Jonathan W. Boyd, Richard R. Neubig

ISBN: 978-1-119-06026-0 April 2019 288 Pages

 Hardcover

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$150.00

Description

Covering a key topic due to growing research into the role of signaling mechanisms in toxicology, this book focuses on practical approaches for informatics, big data, and complex data sets.

  • Combines fundamentals / basics with experimental applications that can help those involved in preclinical drug studies and translational research
  • Includes detailed presentations of study methodology and data collection, analysis, and interpretation
  • Discusses tools like experimental design, sample handling, analytical measurement techniques

List of Contributors

About the Editors

Preface

Chapter 1: Introduction to cellular signal transduction: The connection between a biological system and its surroundings
Jonathan Boyd, Richard Neubig, Alice Han, Maren Prediger

Chapter 2: Mechanisms of cellular signal transduction
Richard Neubig, Jonathan Boyd, Julia Mouch, Nicole Prince

Chapter 3: From cellular mechanisms to physiological responses: Functional signal integration across multiple biological levels
Robert Newman

Chapter 4: Signal transduction in disease: Relating cell signaling to morbidity and mortality
Patricia E. Ganey, Sean E. Misek

Chapter 5: Experimental design in signal transduction
Weimin Gao, Meghan Cromie, Qian Wang, Zhongwei Liu, Song Tang, Julie Miller

Chapter 6: Techniques for measuring cellular signal transduction
Julie Miller, Weimin Gao, Meghan Cromie

Chapter 7: Computational methods for signal transduction: A network approach
Giovanni Scardoni, Gabriele Tosadori, John Morris, A. Pegoraro, Sakshi Pratap, Carlo Laudanna, Alice Han

Chapter 8: A toxicological application of signal transduction: Early cellular changes can be indicative of toxicity
Julie Miller, Nicole Prince, Julia Mouch, Jonathan Boyd 

Chapter 9: Future research in signaling 
Jonathan Boyd, Nicole Prince

Index