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Chemistry and Biochemistry of B12



Chemistry and Biochemistry of B12

Ruma Banerjee (Editor)

ISBN: 978-0-471-25390-7 November 1999 929 Pages


A Definitive New Reference for the Latest Advances in B_12 Chemistry and Biochemistry Over the past decade, the field of B_12 research has been revolutionized by such major breakthroughs as the unraveling of the entire biosynthetic pathway for this important vitamin. This comprehensive compendium surveys the wealth of information that has accumulated, covering in one volume virtually all aspects of the field-from physical and inorganic chemistry to enzymology, microbiology, medicine, and diagnostic and therapeutic applications. Edited by Dr. Ruma Banerjee, a highly respected and active member of the B_12 community, this work provides B_12 researchers with a dependable and up-to-date reference on the subject. Leading authorities from five continents explore such new areas as the structural biology of B_12-dependent enzymes, free-radical-mediated reaction mechanisms, biosynthesis, and much more. The role of B_12 in nutrition and disease, and B_12 transport, are also thoroughly examined. Complete with color illustrations and extensive references, Chemistry and Biochemistry of B_12 is a one-of-a-kind resource for biochemists, biophysicists, spectroscopists, microbiologists, molecular biologists, and anyone with an interest in "nature's most beautiful cofactor."

B_12 History (H. Hogenkamp).

X-ray Crystallography of B_12 (B. Kräutler & C. Kratky).

X-Ray Absorption Spectorscopy of B_12: Structural Changes of Intermediate States (M. Chance).

Electronic Structure and Spectra of B_12: From Trans Effects to Protein Conformation I (J. Pratt).

Electronic Structure and Spectra of B_12: From Trans Effects to Protein Conformation II (J. Pratt).

EPR Spectroscopy of B_12-Dependent Enzymes (G. Gerfen).

NMR Spectroscopy of B_12 (K. Brown).

Vibrational Spectroscopy of B_12 and Related Compounds (L. Marzilli & S. Hirota).

Magnetic Field Dependence of Cobalamin Photochemistry and Enzymes (C. Grissom).

Stereospecificity of the Coenzyme B_12 Catalyzed Rearrangements and the Role of Negative Catalysis (J. Retey).

Modeling the Structure of Cobalt Corrins by Molecular Mechanics and Molecular Dynamics Methods (H. Marques).

B_12 Electrochemistry and Organometallic Electrochemical Synthesis (B. Kräutler).


B_12 and Nutrition (S. Stabler).

Inborn Errors of Cobalamin Metabolism (D. Rosenblatt & W. Fenton).

Diagnostic and Therapeutic Analogs of Cobalamin (H. Hogenkamp, et al.).

Intrinsic Factor and Haptocorrin and Their Receptors (D. Alpers & G. Russell-Jones).

Transcobalamin II (S. Rothenberg, et al.).

Mammalian Receptors of Vitamin B_12-Binding Proteins (S. Moestrup & P. Verroust).

Cobalamin Transport in Bacteria (C. Bradbeer).

Biosynthesis of B_12 in the Aerobic Organism Pseudomonas denitrificans (A. Battersby & F. Leeper).

B_12 Biosynthesis: The Anaerobic Pathway (A. Scott, et al.).

Biosynthesis of the 5-6 Dimethylbenzimidazole Moiety of Cobalamin and of the Other Bases Found in Natural Corrinoids (P. Renz).

Regulation of Adenosylcobalamin Biosynthesis in Salmonella typhimurium (J. Semerena).

X-ray Crystallography of B_12 Enzymes: Methylmalonyl-CoA Mutase and Methionine Synthase (M. Ludwig & P. Evans).

The Acetogenic Corriniod Proteins (S. Ragsdale).

The Role of Corrinoids in Methanogenesis (K. Sauer & R. Thauer).

Methionine Synthase (R. Matthews).

Methylmalonyl-CoA Mutase (R. Banerjee & S. Chowdhury).

Ribonucleotide Reductases (M. Fontecave & E. Mulliez).

Glutamate Mutase and 2-Methyleneglutarate Mutase (W. Buckel, et al.).

Diol Dehydrase and Glycerol Dehydrase (T. Toraya).

Ethanolamine Ammonia-Lyase (V. Bandarian & G. Reed).

Anomutases (P. Frey).

Isobutyryl-CoA Mutase (K. Zerbe-Burkhardt, et al.).

Reductive Dehalogenases (G. Wohlfarth & G. Diekert).