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Classics in Total Synthesis: Targets, Strategies, Methods

Classics in Total Synthesis: Targets, Strategies, Methods

K. C. Nicolaou, E. J. Sorensen

ISBN: 978-3-527-29231-8

Apr 1996

821 pages

Select type: Paperback

In Stock

$119.00

Description

K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry

This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists.

To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information.

Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins.

Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.

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Constructing the Molecules of Nature
Strychnine (Woodward)
Strychnine (Overman)
Penicillin V (Sheehan)
Reserpine (Woodward)
Vitamin B12 (Woodward)
Progesterone (Johnson)
Prostaglandins F2-alpha and E2 (Corey)
Prostaglandins A2 and F2-alpha (Stork)
Carpanone (Chapman)
Monensin (Kishi)
Monensin (Still)
Biotin (Baggiolini)
Periplanone B (Still)
Periplanone B (Schreiber)
Isocomene (Pirrung)
Estrone (Vollhardt)
Erythronolide B (Corey)
Endiandric Acids A-G (Nicolaou)
Thienamycin (Merck)
Asteltoxin (Schreiber)
Amphotericin B (Nicolaou)
L-Hexoses (Masamune & Sharpless)
Cytovaricin (Evans)
Indolizamycin (Danishefsky)
Ginkgolide B (Corey)
Paoniflorigenin and Paoniflorin (Corey)
Methyl homosecodaphniphyllate (Heathcock)
Gilvocarcin M and V (Suzuki)
Calicheamicin gamma-1I (Nicolaou)
Taxol (Nicolaou)
Rapamycin (Nicolaou)
Menthol (Noyori)
Palytoxin (Kishi)
Brevetoxin B (Nicolaou)
  • The main author (Nicolaou) is a top-notch US chemist, who is now regarded as the world's leading synthetic chemist.
  • To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically.
  • The authors carefully explain each synthetic step and give hints on alternative methods and potential pitfalls.
  • Numerous references to useful reviews and the original literature make this book an indispensable source of further information.
  • Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text.
  • For easy reference, key intermediates are also shown in the margins.
  • Didactically skillful approach, reflecting the (world-wide) standard way of teaching organic synthesis (introduction, retrosynthetic analysis, synthesis).
  • Excellent graphics and two colours throughout: Reaction sequences and synthetically crucial steps are presented in (blue) boxed sections. Important formulas are, in addition, depicted in the margin, next to the passage where they are mentioned in the text.
  • Copious references to reviews and the original literature make this book a gold mine of information for every organic chemist in industry and academia.