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Combinatorial Chemistry: A Practical Approach

Combinatorial Chemistry: A Practical Approach

Willi Bannwarth (Editor), Eduard Felder (Editor), Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), Hendrik Timmerman (Series Editor)

ISBN: 978-3-527-61414-1

Mar 2008

450 pages

Select type: O-Book

Description

As we enter the new millennium, combinatorial chemistry is providing significant impetus to new innovations in synthetic chemistry. Combinatorial chemistry has rapidly become the rising star among research methods, allowing scientists to efficiently test the feasibility of a multitude of new compounds.
The pursuit of new drugs is but one challenging field in which these combinatorial methods are particularly advantageous, helping researchers meet the modern-day demands of a highly competitive environment.
This book emphasises that modern combinatorial synthesis is possible not only in the solid phase, but also in solutions. Moreover, it discusses computer-assisted methods as well as the apparatus and instrumentation required for the combinatorial method. Successful and experienced researchers in the leading pharmaceutical companies and most renowned research institutes offer a solid insight and perspective into this diverse field.
A 'must' for every scientist in the area of pharmaceutical research
GENERAL INTRODUCTION
COMBINATORIAL CHEMISTRY IN SOLUTION
Introduction
Multicomponent Condensations
Purification in High Speed Solution-Phase Synthesis
SOLID-PHASE CHEMISTRY
Linkers for Solid-Phase Organic Synthesis and Combinatorial Approaches on Solid Support
Cyclative Cleavage: A Versatile Concept in Solid-Phase Organic Chemistry
C-C Bond Forming Reactions
Combinatorial Synthesis of Heterocycles
POLYMER SUPPORTED REAGENTS: PREPARATION AND USE IN PARALLEL ORGANIC SYNTHESIS
ENCODING STRATEGIES FOR COMBINATORIAL CHEMISTRY
DEVICES FOR COMBINATORIAL SYNTHESIS
COMPUTER-ASSISTED LIBRARY DESIGN
"...this book is recommended to newcomers in the field of combinatorial chemical synthesis because of its broad scope." (Journal of the American Chemical Society, Vol. 123, No. 35)